Pacific Biosciences of California Inc. (PacBio) has announced the introduction of CiFi, a new long-read 3C (chromatin conformation capture) method developed in collaboration with researchers at the University of California, Davis. The results, which have already been published in Nature Communications, demonstrate that CiFi enables chromosome-scale, haplotype-resolved genome assemblies from a single sequencing run, even with limited sample material. By integrating 3C with PacBio’s HiFi long-read sequencing technology, CiFi produces highly accurate, multi-contact reads that improve mapping in repetitive genomic regions and simplify project workflows. In tests using prairie and meadow vole samples, the method delivered uncurated assemblies with scaffold N50 values exceeding 100 million base pairs and detected telomeric sequences at both ends of many scaffolds. The research highlights CiFi’s potential to lower costs and complexity for genome projects previously constrained by sample availability or budget.
Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Pacific Biosciences of California Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: 9622070) on January 08, 2026, and is solely responsible for the information contained therein.
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