Akebia Therapeutics Doses First Patient in Phase 2 Trial of Praliciguat for FSGS

Reuters01-06

Akebia <a href="https://laohu8.com/S/LENZ">Therapeutics</a> Doses First Patient in Phase 2 Trial of Praliciguat for FSGS

Akebia Therapeutics Inc. has announced the dosing of the first patient in a Phase 2 clinical trial evaluating praliciguat, an oral, once-daily soluble guanylate cyclase (sGC) stimulator, for the treatment of biopsy-confirmed focal segmental glomerulosclerosis $(FSGS)$, a rare kidney disease. The randomized, double-blind, placebo-controlled, multicenter study will enroll approximately 60 adults with FSGS who are already receiving maximally tolerated doses of an ACE inhibitor or angiotensin receptor blocker. The trial’s primary endpoint is the change from baseline in urine protein-to-creatinine ratio (UPCR) at Week 24. A secondary endpoint will assess the percentage of patients achieving partial remission at Week 24. All participants will receive praliciguat during an additional 24-week open-label extension period. Study results have not yet been presented and will be provided in the future.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Akebia Therapeutics Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9620380-en) on January 06, 2026, and is solely responsible for the information contained therein.

Disclaimer: Investing carries risk. This is not financial advice. The above content should not be regarded as an offer, recommendation, or solicitation on acquiring or disposing of any financial products, any associated discussions, comments, or posts by author or other users should not be considered as such either. It is solely for general information purpose only, which does not consider your own investment objectives, financial situations or needs. TTM assumes no responsibility or warranty for the accuracy and completeness of the information, investors should do their own research and may seek professional advice before investing.

Comments

We need your insight to fill this gap

Leave a comment

{"i18n":{"language":"en_US"},"isChannel":false,"data":{"share":"https://ttm.financial/m/news/2601897502?lang=en_US&edition=fundamental","thumbnail":"","is_english":true,"pubTime":"2026-01-06 21:00","share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","id":"2601897502","market":"nz","top_or_hot":-1,"title":"Akebia Therapeutics Doses First Patient in Phase 2 Trial of Praliciguat for FSGS","media":"Reuters","content":"<html xmlns=\"http://www.w3.org/1999/xhtml\" xmlns:newsg2=\"http://iptc.org/std/nar/2006-10-01/\" xmlns:xhtml=\"http://www.w3.org/1999/xhtml\"><head><title>\n      Akebia <a href=\"https://laohu8.com/S/LENZ\">Therapeutics</a> Doses First Patient in Phase 2 Trial of Praliciguat for FSGS\n    </title></head><body><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<p>\n        Akebia Therapeutics Inc. has announced the dosing of the first patient in a Phase 2 clinical trial evaluating praliciguat, an oral, once-daily soluble guanylate cyclase (sGC) stimulator, for the treatment of biopsy-confirmed focal segmental glomerulosclerosis <a href=\"https://laohu8.com/S/FSGS\">$(FSGS)$</a>, a rare kidney disease. The randomized, double-blind, placebo-controlled, multicenter study will enroll approximately 60 adults with FSGS who are already receiving maximally tolerated doses of an ACE inhibitor or angiotensin receptor blocker. The trial’s primary endpoint is the change from baseline in urine protein-to-creatinine ratio (UPCR) at Week 24. A secondary endpoint will assess the percentage of patients achieving partial remission at Week 24. All participants will receive praliciguat during an additional 24-week open-label extension period. Study results have not yet been presented and will be provided in the future.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<p>\n<i>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Akebia Therapeutics Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9620380-en) on January 06, 2026, and is solely responsible for the information contained therein.</span></i>\n</p>\n</div></body></html>","source":null,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>Akebia Therapeutics Doses First Patient in Phase 2 Trial of Praliciguat for FSGS</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nAkebia Therapeutics Doses First Patient in Phase 2 Trial of Praliciguat for FSGS\n</h2>\n\n<h4 class=\"meta\">\n\n\n<a class=\"head\" href=\"https://laohu8.com/wemedia/1032215980\">\n\n\n<div class=\"h-thumb\" style=\"background-image:url(https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48);background-size:cover;\"></div>\n\n<div class=\"h-content\">\n<p class=\"h-name\">Reuters </p>\n<p class=\"h-time\">2026-01-06 21:00</p>\n</div>\n\n</a>\n\n\n</h4>\n\n</header>\n<article>\n<html xmlns=\"http://www.w3.org/1999/xhtml\" xmlns:newsg2=\"http://iptc.org/std/nar/2006-10-01/\" xmlns:xhtml=\"http://www.w3.org/1999/xhtml\"><head><title>\n      Akebia <a href=\"https://laohu8.com/S/LENZ\">Therapeutics</a> Doses First Patient in Phase 2 Trial of Praliciguat for FSGS\n    </title></head><body><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<p>\n        Akebia Therapeutics Inc. has announced the dosing of the first patient in a Phase 2 clinical trial evaluating praliciguat, an oral, once-daily soluble guanylate cyclase (sGC) stimulator, for the treatment of biopsy-confirmed focal segmental glomerulosclerosis <a href=\"https://laohu8.com/S/FSGS\">$(FSGS)$</a>, a rare kidney disease. The randomized, double-blind, placebo-controlled, multicenter study will enroll approximately 60 adults with FSGS who are already receiving maximally tolerated doses of an ACE inhibitor or angiotensin receptor blocker. The trial’s primary endpoint is the change from baseline in urine protein-to-creatinine ratio (UPCR) at Week 24. A secondary endpoint will assess the percentage of patients achieving partial remission at Week 24. All participants will receive praliciguat during an additional 24-week open-label extension period. Study results have not yet been presented and will be provided in the future.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<p>\n<i>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Akebia Therapeutics Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9620380-en) on January 06, 2026, and is solely responsible for the information contained therein.</span></i>\n</p>\n</div></body></html>\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"SG9999014039.USD","symbol_name":"UNITED GLOBAL DURABLE EQUITIES (USDHDG) INC","start_time":0,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260106:nNDL6Xm0wt:1","article_id":"2601897502","we_media_id":"1032215980","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2601897502","pubTimestamp":1767704435,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Reuters","introduction":"Reuters.com brings you the latest news from around the world, covering breaking news in markets, business, politics, entertainment and technology","home_visible":1,"id":"1032215980","head_image":"https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48"},"summary":"Akebia Therapeutics Inc. has announced the dosing of the first patient in a Phase 2 clinical trial evaluating praliciguat, an oral, once-daily soluble guanylate cyclase  stimulator, for the treatment of biopsy-confirmed focal segmental glomerulosclerosis , a rare kidney disease. The randomized, double-blind, placebo-controlled, multicenter study will enroll approximately 60 adults with FSGS who are already receiving maximally tolerated doses of an ACE inhibitor or angiotensin receptor blocker. The trial’s primary endpoint is the change from baseline in urine protein-to-creatinine ratio  at Week 24. A secondary endpoint will assess the percentage of patients achieving partial remission at Week 24. All participants will receive praliciguat during an additional 24-week open-label extension period. Study results have not yet been presented and will be provided in the future.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT ","collect":0,"end_time":0,"defaultTopTitle":"","property":[],"viewcount":null,"language":"en","relate_stocks":{"SG9999014039.USD":"UNITED GLOBAL DURABLE EQUITIES (USDHDG) INC","LU2210149790.SGD":"Natixis Thematics Subscription Economy R/A SGD-H","SG9999014013.SGD":"United Global Durable Equities Fund Dis SGD","BK4588":"碎股","IE00B64PRP62.GBP":"GUINNESS GLOBAL MONEY MANAGERS \"C\" (GBP) ACC","IE00B3QW5Z07.USD":"GUINNESS GLOBAL MONEY MANAGERS \"C\" (USD) ACC","AKBA":"Akebia Therapeutics, Inc.","LU0314104364.USD":"MANULIFE GF AMERICAN GROWTH \"AA\" (USD) INC","LU2095319765.USD":"Natixis Thematics Subscription Economy R/A USD","BK4139":"生物科技","BK4585":"ETF&股票定投概念","IE00BKPKM429.USD":"NEUBERGER BERMAN GLOBAL SUSTAINABLE EQUITY \"A\" (USD) ACC","SG9999014005.SGD":"United Global Durable Equities Fund Acc SGD","NDAQ":"纳斯达克OMX交易所","SG9999014021.USD":"UNITED GLOBAL DURABLE EQUITIES (USDHDG) ACC","IE00BGHQF748.EUR":"GUINNESS GLOBAL MONEY MANAGERS \"C\" (EUR) ACC","LU2210150020.SGD":"Natixis Thematics Subscription Economy R/A SGD","BK4112":"金融交易所和数据"},"translate_title":"Akebia Therapeutics在Praliciguat治疗FSGS的2期试验中为首例患者给药","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"AKBA":0.9,"NDAQ":0.9},"content_text":"Akebia Therapeutics Doses First Patient in Phase 2 Trial of Praliciguat for FSGS\n    \n\n        Akebia Therapeutics Inc. has announced the dosing of the first patient in a Phase 2 clinical trial evaluating praliciguat, an oral, once-daily soluble guanylate cyclase (sGC) stimulator, for the treatment of biopsy-confirmed focal segmental glomerulosclerosis $(FSGS)$, a rare kidney disease. The randomized, double-blind, placebo-controlled, multicenter study will enroll approximately 60 adults with FSGS who are already receiving maximally tolerated doses of an ACE inhibitor or angiotensin receptor blocker. The trial’s primary endpoint is the change from baseline in urine protein-to-creatinine ratio (UPCR) at Week 24. A secondary endpoint will assess the percentage of patients achieving partial remission at Week 24. All participants will receive praliciguat during an additional 24-week open-label extension period. Study results have not yet been presented and will be provided in the future.\n      \n\n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Akebia Therapeutics Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9620380-en) on January 06, 2026, and is solely responsible for the information contained therein.","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"dataReport","news_rank":0,"symbols":[],"gpt_button":0,"need_auth":false,"code":"91000000","status":"200"},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":true,"tenantId":"TBGLOBAL","deviceId":"web-server-community-laohu8-v3","version":"4.36.0","shortVersion":"4.36.0","platform":"web","vendor":"web","appName":"ttm","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2601897502","isCrawlerRequest":true}