Bristol Myers Squibb announced positive topline results from the Phase 3 SCOUT-HCM trial evaluating Camzyos (mavacamten) in adolescents aged 12 to under 18 years with symptomatic obstructive hypertrophic cardiomyopathy (oHCM). The trial met its primary endpoint, showing a statistically significant reduction in Valsalva left ventricular outflow tract (LVOT) gradient at Week 28 compared to placebo. Multiple secondary endpoints were also met. The overall safety results were consistent with the established safety profile of Camzyos in adults, with no new safety signals observed in the adolescent population. Detailed results will be presented at an upcoming medical congress and discussed with health authorities.
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