Insilico Medicine Launches Phase IIa Trial of AI-Discovered Drug Garutadustat for Inflammatory Bowel Disease

Reuters01-12

Insilico Medicine Launches Phase IIa Trial of AI-Discovered Drug Garutadustat for Inflammatory Bowel Disease

Insilico Medicine Cayman Topco has announced the completion of the first patient first dose in BETHESDA, a Phase IIa clinical trial for Garutadustat (ISM5411), an AI-driven, gut-restricted PHD inhibitor for the treatment of inflammatory bowel disease. The preclinical development of ISM5411 was previously published in Nature Biotechnology, highlighting the company’s AI-driven drug discovery approach. Results from the Phase IIa trial have not yet been presented and will be available in the future.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Insilico Medicine Cayman Topco published the original content used to generate this news brief via IIS, the Issuer Information Service operated by the Hong Kong Stock Exchange (HKex) (Ref. ID: HKEX-EPS-20260112-11987085), on January 12, 2026, and is solely responsible for the information contained therein.

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