ImmunityBio Inc. has announced updated efficacy and safety results from the ongoing QUILT-106 clinical study (NCT06334991), evaluating an off-the-shelf allogeneic CD19 chimeric antigen receptor natural killer cell therapy (CAR-NK) in combination with rituximab for patients with Waldenström Non-Hodgkin's lymphoma. The results, which have already been presented, show durable complete responses lasting up to 15 months and ongoing, with 100% disease control observed to date in patients who had exhausted standard therapies. The therapy was administered without chemotherapy or lymphodepletion, and all treatments were conducted in the outpatient setting with no serious adverse events reported.
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