Johnson & Johnson has announced new real-world, head-to-head evidence comparing ERLEADA® and darolutamide in patients with metastatic castration-sensitive prostate cancer (mCSPC) who were treated without docetaxel. According to the retrospective study, ERLEADA® was associated with a statistically significant 51 percent reduction in the risk of death compared to darolutamide over 24 months of follow-up (hazard ratio [HR] 0.49; 95% confidence interval [CI], 0.30-0.83; P=0.007). The study utilized propensity score matching and inverse probability of treatment weighting to balance baseline characteristics between groups. Results from this analysis were presented at the 36th Annual International Prostate Cancer Update on February 2, 2026.
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