Calidi Biotherapeutics Inc. published a medical research poster on the RedTail systemic gene therapy platform focused on tumor-specific delivery and localized expression of immune-activating payloads, including an IL-15 superagonist and bispecific T-cell engagers (BiTEs). The document describes the use of an engineered extracellular enveloped vaccinia virus designed for systemic administration, selective tumor replication, oncolysis, and complement resistance via CD55, and includes preclinical findings on tumor-localized payload levels, immune cell activation, and responses in a breast tumor model. The full document can be accessed through the link below.
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