Enveric Biosciences (NASDAQ: ENVB) announced new mechanistic data from proprietary bioluminescence resonance energy transfer (BRET) assays evaluating its lead candidate EB-003. The company reported that EB-003 activates both Gq- and β-arrestin-mediated signaling downstream of the 5-HT₂A receptor and shows a modest preference toward β-arrestin signaling relative to serotonin. The results have already been presented in the announcement, and Enveric said it plans additional BRET testing, including evaluation of the Gi pathway, as it advances EB-003 through IND-enabling studies.
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