ARK Unplugged: How Cathie Wood Crushed the S&P 500 in 2025

Benzinga04:52

ARK Invest's 2025 performance data has been finalized, offering a comprehensive look back at the stocks Cathie Wood identified as underappreciated going into the previous year. Robinhood Markets, Inc...

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comprehensive look back at the stocks Cathie Wood identified as underappreciated going into the previous year. \nRobinhood Markets, Inc. (NASDAQ:HOOD) emerged as the primary driver of growth for Ark's portfolio over the last year. ending 2025 with a 204% gain. \nThe firm noted that Robinhood successfully transitioned from a meme-stock trading app into a full-service financial hub. \nIts expansion into international brokerage services and the successful rollout of its credit card product helped diversify its revenue streams and attract a more stable asset base throughout the year.\nWood's long-standing thesis that software would eventually capture more value than hardware was validated as Palantir secured numerous high-value enterprise contracts.\nAdvanced Micro Devices, Inc. (NASDAQ:AMD) provided a solid 77% return for the year. \nAlthough competition remains intense, AMD secured vital partnerships with major hyperscalers for its AI accelerators. \nAccording to Ark, AMD's continued market share gains in the x86 server CPU market, particularly with its EPYC processors, helped sustain its valuation even as the semiconductor cycle faced pockets of softness.\nFocusing on operational efficiency allowed Shopify to maintain its dominant market position despite a complex consumer spending environment, according to ARK. \nNot all of Wood's selections fared as well and the firm defines weak performers as positions held throughout 2025 that declined by more than 30%. \nDespite these pullbacks—often driven by short-term market scrutiny—ARK maintains steadfast conviction in these companies’ long-term platform objectives.\nRecursion Pharmaceuticals (NASDAQ:RXRX) fell 40% in 2025 as the company rationalized its portfolio, discontinuing several programs with limited clinical activity while integrating the Exscientia acquisition. \nWith a new CEO effective January 2026 and ongoing validation from partners like Roche and Genentech, ARK expects the company to increasingly translate its massive biological datasets into high-conviction clinical candidates.\nTwist Bioscience Corp. (NASDAQ:TWST) saw a 32% decline, primarily due to temporary headwinds in government research funding and a strategic spin-out of its DNA data storage business. \nARK noted a minor revenue “air pocket” from a large customer transition also weighed on shares late in the year. Nevertheless, the firm views Twist's silicon-based DNA synthesis remains a critical, low-cost enabler for the genomics industry. \nPhoto: Shutterstock\nThis content was partially produced with the help of AI tools and was reviewed and published by Benzinga editors.\nTo add Benzinga News as your preferred source on Google, click here.","kind":"news","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"0","news_tag":"","news_rank":0,"symbols":[],"gpt_button":0,"need_auth":false,"code":"91000000","status":"200"},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":true,"tenantId":"TBGLOBAL","deviceId":"web-server-community-laohu8-v3","version":"4.36.2","shortVersion":"4.36.2","platform":"web","vendor":"web","appName":"ttm","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2614874086","isCrawlerRequest":true}