Hansoh Pharmaceutical Group Co., Ltd. announced that Phase 2 data for risvutatug rezetecan (HS-20093 / GSK5764227), a B7-H3-targeted antibody-drug conjugate, were presented at the 2026 ASCO Genitourinary Cancers Symposium. The ARTEMIS-003 (NCT06001255) open-label, multicenter study is evaluating the drug in patients with metastatic castration-resistant prostate cancer who progressed after at least one prior systemic therapy, using an 8.0 mg/kg dose every three weeks, with objective response rate assessed per combined RECIST v1.1 and PCWG3 criteria as the primary endpoint. In taxane-pretreated patients, the combined objective response rate was 38.9% and the combined PSA50 response rate was 40.7%; in taxane-naïve patients, the unconfirmed objective response rate was 41.7% and the unconfirmed PSA50 rate was 23.8%, with enrollment ongoing and updated results pending. The most common grade 3 or higher treatment-related adverse events reported at an incidence of at least 20% were decreased neutrophil count and anemia.
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