Hansoh Pharmaceutical Group Co. Ltd. reported that results from expansion cohorts of the ARTEMIS-001 first-in-human Phase 1a/1b trial (NCT05276609) of risvutatug rezetecan (HS-20093/GSK5764227), a B7-H3-targeted antibody-drug conjugate, in previously treated advanced solid tumors have been published in Cancer Cell. In lung cancer cohorts, confirmed objective response rates were 52.3% in extensive-stage small cell lung cancer (N=65) and 22.4% in non-small cell lung cancer (N=152), with median overall survival of 13.0 and 13.7 months, respectively; 8.0 mg/kg every three weeks was selected for Phase 3 development. The results have already been presented via publication, and the company said confirmatory Phase 3 studies in second-line SCLC are underway in China and globally, with additional pivotal lung cancer studies planned.
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