Insilico Medicine Cayman TopCo reported that ISM4808, an AI-driven prolyl hydroxylase domain inhibitor for chronic kidney disease-related anemia that was previously out-licensed to TaiGen Biotechnology, has enrolled and dosed the first subject in a Phase I clinical trial. The randomized, double-blind, placebo-controlled study includes single-ascending-dose and multiple-ascending-dose cohorts and is designed to assess safety, tolerability, and pharmacokinetics in healthy adults. No clinical results were presented in the announcement, and the company did not specify when results will be presented.
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