Incannex Healthcare Inc. announced an updated clinical development plan for its obstructive sleep apnea candidate IHL-42X that includes initiating a Phase 2 crossover dose-optimization study (DReAMzz) to test multiple ratios of dronabinol and acetazolamide and select an optimal formulation. The company said it has appointed a contract research organization and expects to begin dosing patients in the coming months. Incannex plans to use results from DReAMzz to support a streamlined Phase 3 program, potentially run under a single master protocol with parallel studies, with the goal of optimizing efficacy, maintaining safety, and supporting a more efficient pathway toward potential registration.
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