Press Release: Gyre Therapeutics Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Business Update

Dow Jones03-12

Full-year 2025 revenue increased 10% year-over-year to $116.6 million, within revised guidance range

Full year 2026 revenue guidance of $100.5 to $111.0 million

Entered into agreement to acquire Cullgen to gain targeted protein degradation platform and pipeline; transaction anticipated to close in the second quarter of 2026

Alignment with China's Center for Drug Evaluation $(CDE)$ on conditional approval filing and priority review eligibility for Hydronidone, subject to formal approval; New Drug Application (NDA) submission for conditional approval expected in the first half of 2026

Completed patient enrollment in the 52-week Phase 3 pirfenidone pneumoconiosis $(PD)$ trial

(272 patients across 18 sites)

Hydronidone U.S. Investigational New Drug $(IND)$ application for MASH-associated liver fibrosis anticipated in 2026

SAN DIEGO, March 12, 2026 (GLOBE NEWSWIRE) -- Gyre Therapeutics (Gyre or the Company) (Nasdaq: GYRE), an innovative, commercial-stage biopharmaceutical company dedicated to advancing fibrosis-first therapies across organ systems affected by chronic disease, today announced financial results for the fourth quarter and full year ended December 31, 2025 and provided a business update.

"2026 is expected to be a pivotal regulatory year for Gyre as we advance Hydronidone toward conditional approval in China following our alignment with China's CDE," said Ping Zhang, Executive Chairman and Interim Chief Executive Officer of Gyre Therapeutics. "Our planned NDA submission in the first half of 2026 underscores the strength of our Phase 3 data and the constructive progress achieved through regulatory engagement. In addition, we have completed enrollment in our 52-week Phase 3 pirfenidone trial in pneumoconiosis, further strengthening our late-stage respiratory portfolio. We have also incorporated the complete Phase 2 and Phase 3 clinical data from our CHB-associated liver fibrosis program into our U.S. development strategy and expect to submit an IND application in 2026 for MASH-associated liver fibrosis. Finally, we recently announced an agreement to acquire Cullgen, a company with a robust pipeline of degraders, targeting inflammatory diseases and cancers, as well as U.S.-based drug discovery and development capabilities. Collectively, these achievements support the continued advancement of our differentiated pipeline across both China and the United States."

Fourth Quarter 2025 Business Highlights and Upcoming Milestones

Commercial Portfolio

   -- ETUARY$(R)$ (pirfenidone): Generated $106.1 million in sales of ETUARY(R) 
      for the full year ended December 31, 2025, compared to $105.0 million for 
      the same period in 2024. 
 
   -- Etorel(R) (nintedanib ethanesulfonate soft capsules): Launched in June 
      2025 and generated $4.6 million in sales for the full year ended 
      December 31, 2025. 
 
   -- Contiva(R) (avatrombopag maleate tablets): Launched in March 2025 and 
      generated $5.5 million in sales for the full year ended December 31, 
      2025. 

Pipeline Development Updates

Hydronidone:

   -- In November 2025, Gyre Pharmaceuticals Co., Ltd. (Gyre Pharmaceuticals) 
      presented positive Phase 3 trial results evaluating Hydronidone for the 
      treatment of liver fibrosis in chronic hepatitis B $(CHB)$-associated liver 
      fibrosis at The Liver Meeting(R) 2025, the annual meeting of the American 
      Association of the Study of Liver Diseases. The abstract was selected as 
      a Poster of Distinction. 
 
   -- Following the Phase 3 trial results, Gyre Pharmaceuticals completed a 
      Pre-NDA meeting with China's CDE. Based on the discussions, the CDE 
      indicated that the existing Phase 3 clinical data support a conditional 
      approval filing and potential priority review eligibility, subject to 
      formal acceptance and approval. The Company plans to submit an NDA for 
      conditional approval in the first half of 2026. 
 
   -- In the United States, Gyre Therapeutics plans to conduct a hepatic 
      impairment study under its active U.S. IND application to inform dose 
      selection and enrollment criteria in patients with reduced hepatic 
      function, supporting the Company's broader U.S. development strategy. 
 
   -- Gyre Therapeutics remains on track to submit an IND application in 2026 
      with the U.S. Food & Drug Administration for Hydronidone in 
      MASH-associated liver fibrosis, and, subject to IND clearance, initiate a 
      Phase 2 clinical trial. 

Pirfenidone:

   -- In the third quarter of 2025, Gyre Pharmaceuticals completed patient 
      enrollment in its 52-week Phase 3 clinical trial evaluating pirfenidone 
      for the treatment of PD. The multicenter, randomized, double-blind, 
      placebo-controlled trial enrolled 272 patients across 18 clinical 
      research centers in China and is designed to assess the efficacy and 
      safety of 52 weeks of pirfenidone treatment in patients with this chronic 
      occupational lung disease characterized by progressive pulmonary 
      fibrosis. The final patient is expected to complete the trial in the 
      third quarter of 2026. 
 
   -- Following approval in March 2025 from China's National Medical Products 
      Association's (NMPA) for a clinical trial evaluating pirfenidone in 
      oncology-related pulmonary complications, Gyre Pharmaceuticals plans to 
      initiate an adaptive Phase 2/3 trial in the first half of 2026 in China. 
      This trial will evaluate pirfenidone for radiation-induced lung injury 
      (RILI), including cases complicated by immune-related pneumonitis, at 
      leading oncology centers. 

Corporate Updates:

   -- In March 2026, Gyre announced an agreement to acquire Cullgen Inc. 
      (Cullgen), a privately-held, clinical-stage biopharmaceutical company 
      focused on the discovery and development of targeted protein degrader and 
      degrader antibody conjugate therapies, in an all-stock transaction valued 
      at approximately $300 million. Following the closing of the acquisition, 
      expected in the second quarter of 2026, the new combined entity is 
      expected to be a fully integrated biopharmaceutical company with U.S.- 
      and China-based capabilities spanning from discovery to manufacturing and 
      commercialization and covering multiple therapeutic areas, including 
      inflammatory diseases, cancers, and pain. 

Financial Results

Cash Position

As of December 31, 2025, Gyre had cash, cash equivalents, short-term and long-term bank deposits of $75.9 million.

Financial Results for the Three Months Ended December 31, 2025

   -- Revenues: Revenues for the three months ended December 31, 2025 were 
      $37.2 million, compared to $27.9 million for the same period in 2024, 
      representing an increase of $9.3 million, or 33.3% year-over-year. The 
      growth was driven by $1.5 million in Etorel(R) sales and $2.5 million in 
      Contiva(R) sales, as well as a $5.5 million increase in ETUARY(R) sales, 
      partially offset by a $0.2 million decrease in generic drug revenue. The 
      increase in ETUARY(R) sales reflects strengthened commercial execution 
      and the reallocation of marketing resources during the second half of 
      2025. 
 
   -- Cost of Revenues: For the three months ended December 31, 2025, cost of 
      revenues was $1.7 million, compared to $1.2 million for the same period 
      in 2024. The $0.5 million increase was primarily driven by a $0.4 million 
      increase in stock-based compensation expense, and a $0.1 million increase 
      in cost of sales of Etorel(R) and Contiva(R). 
 
   -- Selling and Marketing Expense: Selling and marketing expense for the 
      three months ended December 31, 2025 was $23.8 million, compared to $16.9 
      million for the same period in 2024, representing an increase of $6.9 
      million, or 40.8% year-over-year. The increase was primarily attributable 
      to expanded commercial activities, including a $2.9 million increase in 
      personnel costs driven by higher sales headcount and commissions, a $2.2 
      million increase in stock-based compensation expense, a $1.7 million 
      increase in conference and promotional activities, and a $0.1 million 
      increase in travel and other expenses. 
 
   -- Research and Development Expense: For the three months ended December 31, 
      2025, research and development expense was $4.8 million, compared to $3.7 
      million for the same period in 2024. The $1.1 million increase was 
      primarily driven by a $0.6 million increase in facilities, depreciation 
      and other expenses, attributable mainly to professional and consulting 
      fees incurred in connection with research and development operations, a 
      $0.3 million increase in pre-clinical research costs, a $0.2 million 
      increase in clinical trial costs and a $0.3 million increase in staff 
      costs which included $0.2 million in stock-based compensation expenses, 
      partially offset by a $0.3 million decrease in materials and utilities 
      expenses. 
 
   -- General and Administrative Expense: For the three months ended 
      December 31, 2025, general and administrative expense was $6.7 million, 
      compared to $5.5 million for the same period in 2024. The $1.2 million 
      increase was primarily driven by a $1.2 million increase in stock-based 
      compensation expense and a $0.8 million increase in functional and 
      administrative department's personnel expense, partially offset by a $0.6 
      million decrease in professional service expense, a $0.1 million decrease 
      in depreciation and amortization expense and a $0.1 million decrease in 
      miscellaneous expense. 
 
   -- Income from Operations: For the three months ended December 31, 2025, 
      income from operations was $0.1 million, compared to $0.7 million income 
      from operations for the same period in 2024. The $0.6 million decrease in 
      income from operations was driven primarily by a $9.9 million increase in 
      total operating expenses, partially offset by a $9.3 million increase in 
      revenue. 
 
   -- Net (Loss) Income: For the three months ended December 31, 2025, net loss 
      was $1.4 million, compared to $0.6 million net income for the same period 
      in 2024. The $2.0 million decrease was driven primarily by an increase in 
      income tax expense of $1.1 million, an increase in operating expenses of 
      $9.9 million and a decrease in other income of $0.3 million, partially 
      offset by an increase in revenue of $9.3 million. 
 
   -- Non-GAAP Adjusted Net Income: For the three months ended December 31, 
      2025, non-GAAP adjusted net income was $4.3 million, compared to $1.1 
      million for the same period in 2024. The $3.2 million increase was 
      primarily driven by an increase in revenue of $9.3 million partially 
      offset by the increase in operating expenses of $5.8 million and an 
      decrease in other income of $0.3 million. 

Financial Results for the Full Year Ended December 31, 2025

   -- Revenues: Revenues for the full year ended December 31, 2025 were $116.6 
      million, compared to $105.8 million for the same period in 2024, 
      representing an increase of $10.8 million, or 10.2% year-over-year. The 
      growth was driven by $5.5 million in Contiva(R) sales and $4.6 million in 
      Etorel(R) sales, along with a $1.1 million increase in ETUARY(R) sales, 
      partially offset by a $0.4 million decline in generic drug revenue.Sales 
      of Contiva(R) and Etorel(R), which commenced commercialization in March 
      2025 and June 2025, respectively, were primarily driven by the targeted 
      allocation of commercial and marketing resources to support their 
      respective launches during the first half of 2025. The increase in 
      ETUARY(R) sales reflects a strategic realignment of marketing efforts in 
      the third quarter of 2025 to optimize product mix and address evolving 
      market dynamics. 
   -- Cost of Revenues: For the full year ended December 31, 2025, cost of 
      revenues was $5.4 million, compared to $3.9 million for the same period 
      in 2024. The $1.5 million increase was primarily driven by a $0.8 million 
      increase in ETUARY(R)'s cost, due to higher plant, property and equipment 
      depreciation from a plant renovation completed in the second half of 
      2024, a $0.6 million increase in the cost of Contiva(R) and Etorel(R), in 
      line with the corresponding increase in their sales, and a $0.5 million 
      increase in stock-based compensation expense. These factors were 
      partially offset by a $0.4 million decrease in costs related to generic 
      drugs due to the decrease in sales. 
 
   -- Selling and Marketing Expense: For the full year ended December 31, 2025, 
      selling and marketing expense was $65.2 million, compared to $57.5 
      million for the same period in 2024. This $7.7 million increase was 
      primarily driven by a $2.5 million increase in conference expenses and 
      promotional expenses, attributable to the launch of additional 
      promotional campaigns in the current year--particularly for the Company's 
      new products, a $2.6 million increase in staff costs, which was driven by 
      expanded headcount and higher sales commissions, consistent with the 
      corresponding growth in revenue, a $2.3 million increase in stock-based 
      compensation expense and a $0.3 million increase in traveling and other 
      expense. 
 
   -- Research and Development Expense: For the full year ended December 31, 
      2025, research and development expense was $13.7 million, compared to 
      $12.0 million for the same period in 2024. The $1.7 million increase was 
      attributable to a $1.0 million increase in clinical trial costs, 
      primarily as a result of data analysis costs for Hydronidone, PD and RILI, 
      a $0.4 million increase in staff costs, which included $0.2 million in 
      stock-based compensation expense, a $0.5 million increase in facilities, 
      depreciation and other expenses, attributable mainly to professional and 
      consulting fees incurred in connection with research and development 
      operations, and a $0.4 million increase in pre-clinical research 
      expenses. These expense increases were partially offset by a $0.6 million 
      decrease in materials and utilities expenses. 
 
   -- General and Administrative Expense: For the full year ended December 31, 
      2025, general and administrative expense was $20.8 million, compared to 
      $16.1 million for the same period in 2024. This $4.7 million increase was 
      primarily driven by a $3.3 million increase in stock-based compensation 
      expense, a $1.3 million increase in functional and administrative 
      department's personnel expense, and a $0.9 million increase in 
      miscellaneous expense. These cost increases were partially offset by a 
      $0.8 million decrease in professional service expenses. 
 
   -- Income from Operations: For the full year ended December 31, 2025, income 
      from operations was $11.5 million, compared to $16.2 million in income 
      for the same period in 2024. The $4.7 million decrease in income from 
      operations was driven primarily by a $15.5 million increase in total 
      operating expenses, partially offset by a $10.8 million increase in 
      revenue. 
 
   -- Net Income: For the full year ended December 31, 2025, net income was 
      $9.9 million, compared to $17.9 million net income for the same period in 
      2024. This $8.0 million decrease was driven primarily by the increase in 
      operating expenses of $15.5 million and decrease in change in fair value 
      of warrant liability of $4.5 million, partially offset by an increase in 
      revenue of $10.8 million, an increase in other income of $0.4 million, 
      and a decrease in income tax expense of $0.8 million. 
 
   -- Non-GAAP Adjusted Net Income: For the full year ended December 31, 2025, 
      non-GAAP adjusted net income was $18.9 million, compared to $16.9 million 
      for the same period in 2024. The increase was primarily driven by an 
      increase in revenue of $10.8 million and an increase in other income of 
      $0.4 million partially offset by an increase in operating expenses of 
      $9.2 million. 

Full Year 2026 Financial Guidance

For the full year 2026, the Company expects to generate revenues of $100.5 million to $111.0 million, representing a decline of approximately 13.8% to 4.8% compared to 2025.

The Company anticipates that 2026 will be a transition period, during which it plans to prioritize regulatory activities, including preparation for the planned NDA submission of Hydronidone.

In addition, given uncertainties associated with the National Centralized Drug Procurement program and evolving market dynamics, the Company expects to moderate promotional activities for Contiva(R) and Etorel(R) .

Please note the following regarding the total revenue guidance:

   -- Guidance assumes a constant foreign currency exchange rate. 
 
   -- Guidance assumes no significant economic disruption or downturn. 

Use of Non-GAAP Financial Measures by Gyre Therapeutics, Inc.

Gyre reports financial results in accordance with accounting principles generally accepted in the United States ("GAAP"). This release presents the financial measure "adjusted net income," which is not calculated in accordance with GAAP. The most directly comparable GAAP measure for this non-GAAP financial measure is "net income." Adjusted net income presents Gyre's results of operations after excluding gain from change in fair value of warrants, stock-based compensation, and provision for income taxes. This is meant to supplement, and not substitute, Gyre's financial information presented in accordance with GAAP. Adjusted net income as defined by Gyre may not be comparable to similar non-GAAP measures presented by other companies. Management believes that presenting adjusted net income provides investors with additional useful information in evaluating Gyre's performance and valuation. See the reconciliation of adjusted net income to net income in the section titled "Reconciliation of GAAP to Non-GAAP Financial Measures" below.

About Hydronidone

Hydronidone is a novel, orally administered anti-fibrotic agent designed to target key liver fibrosis pathways. It attenuates hepatic stellate cell activation and fibrogenesis, at least in part, by suppressing Tumor Growth Transforming (TGF)-<BETA>1-induced signal transduction, including reduced p38<GAMMA> phosphorylation and upregulated Smad7 expression. This upregulation of Smad7 subsequently leads to downregulation of TGF-<BETA>RI and inhibition of Smad2/3 activation, thereby disrupting canonical TGF-<BETA>/Smad signaling and reducing fibrotic gene expression in hepatic stellate cells.

The drug has completed Phase 3 clinical evaluation in China for chronic hepatitis B (CHB)-associated liver fibrosis, including early (compensated) cirrhosis, and is being evaluated for its potential applicability across additional fibrotic diseases in region-specific development programs.

About Gyre Pharmaceuticals

Gyre Pharmaceuticals is a commercial-stage biopharmaceutical company committed to the research, development, manufacturing and commercialization of innovative drugs for organ fibrosis. Its flagship product, ETUARY(R) (pirfenidone capsule), was the first approved treatment for IPF in China in 2011 and has maintained a prominent market share (2024 net sales of $105.8 million). In addition, Gyre Pharmaceuticals' pipeline includes Hydronidone, a structural analogue of pirfenidone, which demonstrated statistically significant fibrosis regression after 52 weeks of treatment in a pivotal Phase 3 clinical trial in CHB-associated liver fibrosis in China. Hydronidone received Breakthrough Therapy designation by the NMPA CDE in March 2021. Gyre Pharmaceuticals is also developing treatments for PD, RILI with or without immune-related pneumonitis, chronic obstructive pulmonary disease (COPD), pulmonary arterial hypertension (PAH) and acute/acute-on-chronic liver failure (ALF/ACLF). As of December 31, 2025, Gyre Therapeutics owns a 69.7% equity interest in Gyre Pharmaceuticals.

About Gyre Therapeutics

Gyre Therapeutics is a biopharmaceutical company headquartered in San Diego, CA, primarily focused on the development and commercialization of Hydronidone for liver fibrosis, including MASH, in the United States Gyre's strategy builds on its experience in mechanistic studies using MASH rodent models and clinical studies in CHB-induced liver fibrosis. In the People's Republic of China, Gyre is advancing a broad pipeline through its indirect controlling interest in Gyre Pharmaceuticals, including therapeutic expansions of ETUARY(R) , and development programs for F573, F528, and F230.

Forward-Looking Statements

This press release contains "forward-looking statements" within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995, which statements are subject to substantial risks and uncertainties and are based on estimates and assumptions. All statements, other than statements of historical facts included in this press release, are forward-looking statements, including statements concerning: the expectations regarding Gyre's research and development efforts, the anticipated timing of the submission of Gyre Therapeutics' U.S. IND application for Hydronidone for the treatment of MASH-associated liver fibrosis, plans to conduct a hepatic impairment study of Hydronidone in U.S. subjects under Gyre Therapeutics' active IND application, timing for the initiation of Gyre Pharmaceuticals' Phase 2/3 trial in China for pirfenidone capsules for the treatment of RILI, including cases complicated by immune-related pneumonitis, the filing of an NDA with the NMPA and timing for potential commercial approval for Hydronidone for the treatment of CHB-associated liver fibrosis, expectations regarding conducting a confirmatory trial for Hydronidone in China, trial design of Gyre's Phase 3 clinical trial evaluating pirfenidone for the treatment of pneumoconiosis, interactions with regulators, the structure, timing and completion of the proposed acquisition of Cullgen, the anticipated timing of closing of the acquisition of Cullgen, the future operations of the combined entity, the nature, strategy and focus of the combined Gyre and Cullgen entity, the development and commercial potential and potential benefits of any product candidates of the combined Gyre and Cullgen entity, Gyre's ability to meet its expected revenue guidance and Gyre's financial position and cash resources. In some cases, you can identify forward-looking statements by terms such as "may," "might," "will," "objective," "intend," "should," "could," "can," "would," "expect," "believe," "design," "estimate," "predict," "potential," "plan" or the negative of these terms, and similar expressions intended to identify forward-looking statements. These statements reflect our plans, estimates, and expectations, as of the date of this press release. These statements involve known and unknown risks, uncertainties and other factors that could cause our actual results to differ materially from the forward-looking statements expressed or implied in this press release. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, without limitation: Gyre's ability to execute on its clinical development strategies; positive results from a clinical trial may not necessarily be predictive of the results of future or ongoing clinical trials; the timing or likelihood of regulatory filings and approvals; competition from competing products; the impact of general economic, health, industrial or political conditions in the United States or internationally; the sufficiency of Gyre's capital resources and its ability to raise additional capital; supply chain and distribution delays and challenges. Additional risks and factors are identified under "Risk Factors" in Gyre's Annual Report on Form 10-K for the year ended December 31, 2024, filed on March 17, 2025, and in subsequent filings with the Securities and Exchange Commission.

Gyre expressly disclaims any obligation to update any forward-looking statements whether as a result of new information, future events or otherwise, except as required by law.

For Investors:

David Zhang

Gyre Therapeutics

david.zhang@gyretx.com

 
 
                          Gyre Therapeutics, Inc. 
                    Consolidated Statements of Operations 
             (In thousands, except share and per share amounts) 
 
                        Three Months Ended 
                            December 31, 
                            (Unaudited)            Year Ended December 31, 
                        2025          2024           2025           2024 
                     -----------   -----------   ------------   ------------ 
Revenues             $    37,195   $    27,872   $    116,588   $    105,757 
Operating 
expenses: 
   Cost of revenues        1,743         1,177          5,416          3,884 
   Selling and 
    marketing             23,816        16,856         65,179         57,511 
   Research and 
    development            4,815         3,712         13,698         12,024 
   General and 
    administrative         6,701         5,464         20,804         16,109 
   Loss (Gain) on 
    disposal of 
    assets, net                2            (2)             4             66 
                      ----------    ----------    -----------    ----------- 
    Total operating 
     expenses             37,077        27,207        105,101         89,594 
                      ----------    ----------    -----------    ----------- 
Income from 
 operations                  118           665         11,487         16,163 
Other income 
(expenses): 
   Interest income, 
    net                      509           346          1,747          1,547 
   Other expense, 
    net                     (956)         (433)        (1,505)        (1,659) 
   Change in fair 
    value of 
    warrant 
    liability                263           194          2,707          7,167 
                      ----------    ----------    -----------    ----------- 
(Loss) Income 
 before income 
 taxes                       (66)          772         14,436         23,218 
Provision for 
 income taxes             (1,300)         (203)        (4,556)        (5,320) 
                      ----------    ----------    -----------    ----------- 
Net (loss) income         (1,366)          569          9,880         17,898 
Net income 
 attributable to 
 noncontrolling 
 interest                    357           668          4,853          5,813 
                      ----------    ----------    -----------    ----------- 
Net (loss) income 
 attributable to 
 common 
 stockholders        $    (1,723)  $       (99)  $      5,027   $     12,085 
                      ==========    ==========    ===========    =========== 
Net (loss) income 
per share 
attributable to 
common 
stockholders: 
    Basic            $     (0.02)  $     (0.00)  $       0.06   $       0.14 
                      ==========    ==========    ===========    =========== 
    Diluted          $     (0.02)  $     (0.00)  $       0.02   $       0.05 
                      ==========    ==========    ===========    =========== 
Weighted average 
shares used in 
calculating net 
income per share 
attributable to 
common 
stockholders: 
    Basic             91,156,159    85,952,413     89,344,622     85,094,948 
                      ==========    ==========    ===========    =========== 
    Diluted           91,156,159    85,952,413    103,180,037    102,293,526 
                      ==========    ==========    ===========    =========== 
 
 
 
                       Gyre Therapeutics, Inc. 
                     Consolidated Balance Sheets 
          (In thousands, except share and per share amounts) 
 
                             December 31, 2025     December 31, 2024 
                            -------------------   ------------------- 
Assets 
Current assets: 
   Cash and cash 
    equivalents               $          37,070     $          11,813 
   Short-term bank 
    deposits                             15,355                14,858 
   Notes receivable                       5,638                 4,373 
   Accounts receivable, 
    net                                  31,078                19,589 
   Other receivables from 
    GNI                                     230                   230 
   Inventories                           10,171                 6,337 
   Prepaid assets                         1,338                 1,189 
   Receivable from GCBP                      --                 4,961 
   Other current assets                   1,489                 1,436 
                            ---  --------------   ---  -------------- 
     Total current assets:              102,369                64,786 
   Property and equipment, 
    net                                  23,599                23,880 
   Intangible assets, net                 4,727                   273 
   Right-of-use assets                    1,131                 1,818 
   Land use rights, net                   1,425                 1,432 
   Deferred tax assets                    6,873                 5,619 
   Long-term certificates 
    of deposit                           23,516                24,568 
   Other assets, 
    noncurrent                            2,492                 3,030 
                            ---  --------------   ---  -------------- 
Total assets                  $         166,132     $         125,406 
                            ===  ==============   ===  ============== 
Liabilities, convertible 
preferred stock, and 
equity 
Current liabilities: 
   Accounts payable           $             124     $             108 
   Contract liabilities                      14                    61 
   Due to related parties                   227                   227 
   Accrued expenses and 
    other current 
    liabilities                          14,345                10,615 
   Income tax payable                     2,940                 2,831 
   Operating lease 
    liabilities, current                    636                   713 
   CVR derivative 
    liability                                --                 4,961 
                            ---  --------------   ---  -------------- 
     Total current 
      liabilities:                       18,286                19,516 
   Operating lease 
    liabilities, 
    noncurrent                              303                   885 
   Deferred government 
    grants                                  852                   928 
   Warrant liability, 
    noncurrent                            2,961                 5,668 
   Other noncurrent 
    liabilities                           1,448                     7 
                            ---  --------------   ---  -------------- 
Total liabilities             $          23,850     $          27,004 
Commitments and 
Contingencies 
Stockholders' equity: 
   Common stock, $0.001 
    par value, 400,000,000 
    shares authorized; 
    91,314,007 shares and 
    86,307,544 shares 
    issued and outstanding 
    at December 31, 2025 
    and 2024, 
    respectively                             91                    86 
   Additional paid-in 
    capital                             172,047               136,185 
   Statutory reserve                      3,098                 3,098 
   Accumulated deficit                  (68,426)              (73,453) 
   Accumulated other 
    comprehensive loss                     (779)               (2,597) 
                            ---  --------------   ---  -------------- 
Total Gyre stockholders' 
 equity                                 106,031                63,319 
Noncontrolling interest                  36,251                35,083 
                            ---  --------------   ---  -------------- 
   Total equity                         142,282                98,402 
                            ---  --------------   ---  -------------- 
Total liabilities and 
 stockholders' equity         $         166,132     $         125,406 
                            ===  ==============   ===  ============== 
 
 
 
                   Gyre Therapeutics, Inc. 
    Reconciliation of GAAP to Non-GAAP Financial Measures 
                        (in thousands) 
                         (unaudited) 
 
                Three Months Ended     Years Ended December 
                   December 31,                 31, 
               --------------------   ----------------------- 
                  2025       2024        2025          2024 
               ----------   -------   ----------      ------- 
Net (loss) 
 income         $  (1,366)  $   569    $   9,880      $17,898 
Gain from 
 change in 
 fair value 
 of 
 warrants(1)         (263)     (194)      (2,707)      (7,167) 
Stock-based 
 compensation       4,597       567        7,157          831 
Provision for 
 income 
 taxes              1,300       203        4,556        5,320 
                   ------    ------       ------       ------ 
Non-GAAP 
 adjusted net 
 income         $   4,268   $ 1,145    $  18,886      $16,882 
                   ======    ======       ======       ====== 
 

(1) Reflects adjustments for fair value of warrants based on the Black-Scholes option pricing model.

(END) Dow Jones Newswires

March 12, 2026 06:00 ET (10:00 GMT)

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