Eledon reports 100% insulin independence in 10 patients in tegoprubart islet transplant trial

Reuters03-16

Eledon reports 100% insulin independence in 10 patients in tegoprubart islet transplant trial

Eledon reported updated results from an investigator-initiated pilot study of tegoprubart, an anti-CD40L monoclonal antibody, used in a calcineurin inhibitor-free immunosuppression regimen for allogeneic islet transplantation in adults with long-standing type 1 diabetes at UChicago Medicine. The updated data were presented by Piotr Witkowski at the ATTD conference in Barcelona. The 12-patient cohort was fully enrolled with an average time since transplant of about 8 months. Among 10 patients more than 4 weeks post-transplant, 100% achieved insulin independence and had a most recent HbA1c below 6%. Eledon said there were no graft rejection episodes and no de novo donor-specific HLA antibodies reported in the study.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Eledon Pharmaceuticals Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: 202603160700PRIMZONEFULLFEED9672403) on March 16, 2026, and is solely responsible for the information contained therein.

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