Ascendis published a document summarizing Week 104 results from the pivotal ApproaCH trial open-label extension evaluating once-weekly navepegritide (TransCon CNP) in treatment-naïve children with achondroplasia aged 2 to 11 years. In the double-blind period, annualized growth velocity at Week 52 was 5.89 cm/year for navepegritide and 4.41 cm/year for placebo. The document also reports a least squares mean difference of 1.49 cm/year (95% CI: 1.05 to 1.93) for the Week 52 annualized growth velocity endpoint.
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