ImmunityBio said it completed manufacturing engineering programs NK2022 and NK2023, enrolling 74 subjects across healthy donors and cancer patients. Across NK2022 and NK2023, 64 subjects completed leukapheresis with no procedure-related serious adverse events reported. ImmunityBio said a single apheresis yielded up to 5 billion activated memory cytokine-enhanced NK cells, providing up to 8-10 doses per patient within 12 days. In the QUILT-3.076 Phase 1 cohort, 10 patients received weekly intravenous infusions of 0.25 to 0.75 billion cells per dose, up to 10 doses. The company reported 0% treatment-related adverse events of Grade 4 or 5 and 0% cytokine storm in those 10 patients.
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