Bristol Myers’ Camzyos cuts LVOT gradient in Phase 3 adolescent obstructive HCM trial

Reuters03-29

Bristol Myers’ Camzyos cuts LVOT gradient in Phase 3 adolescent obstructive HCM trial

Bristol Myers Squibb reported positive Phase 3 SCOUT-HCM results for Camzyos (mavacamten) in adolescents with symptomatic obstructive hypertrophic cardiomyopathy.
Trial met primary endpoint, showing least-squares mean Valsalva LVOT gradient reduction versus placebo at Week 28 of 48 mm Hg (P < 0.0001).
Data were presented as a late-breaking presentation at ACC Annual Scientific Session & Expo 2026, with simultaneous publication in New England Journal of Medicine.
Safety profile in adolescents matched adult experience, with no new safety signals reported over 28 weeks.
Study enrolled 44 patients ages 12 to <18, positioning Camzyos as potential first targeted pharmacologic therapy for adolescent oHCM if regulators expand labeling.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Bristol-Myers Squibb Company published the original content used to generate this news brief via Business Wire (Ref. ID: 202603291145BIZWIRE_USPR_____20260327_BW682053) on March 29, 2026, and is solely responsible for the information contained therein.

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0.0001).\n        </li>\n<li>\n          Data were presented as a late-breaking presentation at ACC Annual Scientific Session &amp; Expo 2026, with simultaneous publication in <a href=\"https://laohu8.com/S/NEWEN\">New England</a> Journal of Medicine.\n        </li>\n<li>\n          Safety profile in adolescents matched adult experience, with no new safety signals reported over 28 weeks.\n        </li>\n<li>\n          Study enrolled 44 patients ages 12 to &lt;18, positioning Camzyos as potential first targeted pharmacologic therapy for adolescent oHCM if regulators expand labeling.\n        </li>\n</ul>\n<br/>\n<br/>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<p>\n<i>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. 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