Completed strategic acquisition of dual-targeting CAR-T assets from Factor Bioscience Inc.
Named Matt Angel, Ph.D., Chief Executive Officer & President
Announced positive interim data from the ongoing REDEEM-1 Phase 1/2a trial of TPST-2003 in patients with relapsed/refractory multiple myeloma (rrMM)
BRISBANE, Calif., March 30, 2026 (GLOBE NEWSWIRE) -- Tempest Therapeutics, Inc. (Nasdaq: TPST) ("Tempest"), a clinical-stage biotechnology company developing a pipeline of advanced CAR-T cell therapy product candidates to treat cancer, today reported financial results for the year ended December 31, 2025, and provided a corporate update.
"2025 was a transformative year for Tempest as we strengthened our pipeline with the strategic acquisition of a portfolio of next-generation CAR-T assets," said Matt Angel, Ph.D., President and Chief Executive Officer of Tempest. "The portfolio is already proving potentially fruitful as we reported encouraging early clinical data from our lead CAR-T program, TPST-2003, which is being tested in a Phase 1/2a trial in patients with relapsed or refractory multiple myeloma. The data, which suggests a favorable safety and efficacy profile for TPST-2003, reinforced our belief that this therapy has the potential to differentiate itself from currently approved CAR-T treatments and provide a meaningful option for patients who continue to face limited durable treatment options. We look forward to the potential initiation of a U.S. registrational study of TPST-2003 in patients with rrMM later this year, while we continue our strategy of leveraging partner-funded and externally supported development where possible to advance our pipeline."
2025 & Recent Accomplishments
-- TPST-2003
-- Announced positive interim results from the ongoing REDEEM-1 Phase
1/2a trial of TPST-2003 in patients with rrMM, which is being
sponsored and conducted by Tempest's partner, Novatim Immune
Therapeutics:
-- 100% complete response $(CR)$ rate among all six efficacy
evaluable patients as of the January 31, 2026 data cutoff
-- Favorable safety profile with no Grade >3 cytokine release
syndrome ("CRS") or immune effector cell-associated
neurotoxicity syndrome ("ICANS") appears to be emerging as
a potentially differentiating attribute in its class
-- Prior investigator-initiated trial ("IIT") reached median
progression free survival $(PFS)$ of 23.1 months, including
in patients with extramedullary disease
-- 36 patients with rrMM treated to date across two studies
-- Corporate:
-- Announced closing of strategic acquisition of new dual-targeting
CAR-T assets from Factor Bioscience Inc. and its affiliates
-- All-stock transaction brought Tempest a portfolio of
next-generation CAR-T assets, including TPST-2003, a
clinical-stage dual-targeting CD-19/BCMA CAR-T with
strategic partner-funded biologics license application
(BLA) filing in China planned for 2027
-- In November 2025, announced up to $8.35 million registered direct
offering (an "RDO" and, such offering, the "November Offering") of
common stock and concurrent private placement of warrants priced
at-the-market under Nasdaq
-- In March 2026, announced up to $6 million private placement (the
"2026 Offering") of common stock and warrants, with $2 million
upfront and up to $4 million of potential aggregate gross proceeds
upon the exercise in full of warrants
-- Amezalpat (TPST-1120) (clinical PPAR<ALPHA> antagonist):
-- Received clearance to proceed with pivotal trial of amezalpat
combination therapy for first-line hepatocellular carcinoma
("HCC") in China
-- Granted orphan drug designation from the European Medicines Agency
for amezalpat for the treatment of patients with HCC
-- Reported new data at the 2025 American Association for Cancer
Research (AACR) Annual Meeting supporting the immune component of
amezalpat's dual mechanism of action and reinforcing its potential
as a novel cancer treatment
-- Granted both Orphan Drug and Fast Track designations by the U.S.
Food and Drug Administration ("FDA") for amezalpat for the
treatment of patients with HCC
-- TPST-1495 (clinical dual EP2/4 prostaglandin receptor antagonist)
-- Granted Orphan Drug designation by the FDA to treat patients with
Familial Adenomatous Polyposis ("FAP")
-- Received a "Study May Proceed" letter from the FDA to evaluate
TPST-1495 in a Phase 2 Trial for the treatment of FAP
Potential Future Milestones
-- TPST-2003
-- Present results from the ongoing Phase 1/2a REDEEM-1 study, as
well as updated data from the Phase 1/2 IIT, in 2026
-- Submit a U.S. IND application and, subject to clearance, initiate
a Phase 2b U.S. registrational study of TPST-2003 in patients with
rrMM in 2026
-- TPST-1495
-- Initiate a Phase 2 study of TPST-1495 in FAP, with first patient
enrollment expected in 2026. The study is expected to be funded by
the National Cancer Institute and conducted through the Cancer
Prevention Clinical Trials Network, enabling advancement without
internal capital deployment.
Financial Results
Year End 2025
-- Tempest ended the year with $7.7 million in cash and cash equivalents,
compared to $30.3 million on December 31, 2024. The decrease was
primarily due to cash used in operating activities, offset by net
proceeds from the issuance of common stock of $4.1 million from the RDO
in June, $3.8 million from the November Offering and $2.8 million from
Tempest's at-the-market offering program.
-- Net loss and net loss per share for the year were $26.3 million and
$6.33, respectively, compared to $41.8 million and $19.50, respectively,
for the same period in 2024.
-- Research and development expenses for the year were $12.6 million
compared to $28.5 million for the same period in 2024. The $15.9 million
decrease was primarily due to a decrease in costs incurred as a result of
re-prioritizing efforts towards exploring strategic alternatives.
-- General and administrative expenses for the year were $14.0 million
compared to $13.6 million for the same period in 2024. The $0.4 million
increase was primarily due to one-time separation costs for employees
terminated during the period.
About Tempest Therapeutics
Tempest Therapeutics is a clinical-stage biotechnology company developing a pipeline of CAR-T cell therapy and small molecule product candidates to treat cancer. Tempest is headquartered in Brisbane, California. More information about Tempest can be found on the company's website at https://www.tempesttx.com
Forward-Looking Statements
This press release contains forward-looking statements (including within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and Section 27A of the Securities Act of 1933, as amended (the "Securities Act")) concerning Tempest Therapeutics, Inc. These statements may discuss goals, intentions, and expectations as to future plans, trends, events, results of operations or financial condition, or otherwise, based on current beliefs of the management of Tempest Therapeutics, as well as assumptions made by, and information currently available to, management of Tempest Therapeutics. Forward-looking statements generally include statements that are predictive in nature and depend upon or refer to future events or conditions, and include words such as "may," "will," "should," "would," "could", "expect," "anticipate," "plan," "likely," "believe," "estimate," "project," "intend," and other similar expressions. All statements that are not historical facts are forward-looking statements, including but not limited to, statements regarding: Tempest Therapeutics' plan to present data from clinical trials, including the REDEEM-1 trial; the design, initiation, progress, timing, scope and results of clinical trials, including the anticipated initiation of U.S. registrational trial for TPST-2003 in 2026 and patient enrollment for the Phase 2 study of TPST-1495 in 2026; the planned advancement of a diversified next-generation CAR-T pipeline; anticipated therapeutic benefit and regulatory development of Tempest Therapeutics' product candidates, including TPST-2003, Amezalpat and TPST-1495; the use of proceeds from each of the November 2025 Offering and 2026 Offering, and the potential aggregate proceeds therefrom; and Tempest Therapeutics' ability to achieve its operational plans. Any forward-looking statements in this press release are based on Tempest Therapeutics' current expectations, estimates and projections about its industry as well as management's current beliefs and expectations of future events only as of today and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to Tempest Therapeutics' need for additional capital to fund its planned programs and operations and to continue to operate as a going concern; unexpected safety or efficacy data observed during preclinical or clinical trials; the possibility that results from prior clinical trials and preclinical studies may not necessarily be predictive of
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