Cocrystal Pharma starts Phase 1b human challenge trial of norovirus drug CDI-988

Reuters04-01
<a href="https://laohu8.com/S/COCP">Cocrystal Pharma</a> starts Phase 1b human challenge trial of norovirus drug CDI-988
  • Cocrystal Pharma reported FY 2025 results while starting Phase 1b randomized, double-blind, placebo-controlled human challenge trial of oral norovirus candidate CDI-988 at Emory University School of Medicine.
  • First cohort is underway to confirm infectivity of GII.2 challenge strain, with later cohorts set to receive CDI-988 or placebo.
  • Trial will evaluate whether CDI-988 can lower likelihood of symptomatic illness, with additional readouts on viral shedding, disease severity, safety, pharmacokinetics.
  • Phase 1 safety and tolerability results were already presented in August 2025, supporting continued clinical development.
  • Program targets market with no approved norovirus treatments or vaccines, with global economic burden estimated at USD 60 billion annually.


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