Press Release: NewAmsterdam Pharma Provides Corporate Update and Reports Second Quarter Financial Results

Dow Jones08-05

-- Announced positive CHMP opinion recommending marketing authorization for obicetrapib and obicetrapib/ezetimibe --

-- PREVAIL interim analysis planned for 4Q2026 with result expected in 1Q2027 --

-- Topline data from RUBENS Phase 3 expected by year-end 2026 --

-- $678.3 million in cash, cash equivalents and marketable securities at June 30, 2026 --

-- Company to host investor day today at 9:00 AM ET in New York City --

NAARDEN, the Netherlands and MIAMI, Aug. 05, 2026 (GLOBE NEWSWIRE) -- NewAmsterdam Pharma Company N.V. (Nasdaq: NAMS or "NewAmsterdam" or the "Company"), a late-stage, clinical biopharmaceutical company developing oral, non-statin medicines for patients at risk of cardiovascular disease ("CVD") with elevated low-density lipoprotein cholesterol ("LDL-C"), for whom existing therapies are not sufficiently effective or well-tolerated, today announced financial results for the quarter ended June 30, 2026 and provided a corporate update.

"During the second quarter, we continued to build momentum across our regulatory, clinical, and scientific priorities," said Michael Davidson, M.D., Chief Executive Officer of NewAmsterdam Pharma. "Our quarterly update is headlined by the positive opinion for Europe from CHMP, recommending the granting of a marketing authorization for Ubeslo and Evlarco, intended for the treatment of primary hypercholesterolemia or mixed dyslipidemia. Additionally, supportive analyses presented at NLA and AAIC continue to expand the growing body of evidence supporting the potential of obicetrapib across multiple diseases. As we continue to advance our late-stage development program and prepare for several important regulatory and clinical milestones in the months ahead, we remain focused on disciplined execution and look forward to sharing additional updates on our strategy, pipeline, and priorities during today's Investor Day."

Clinical Development Updates

NewAmsterdam is developing obicetrapib, an oral, low-dose and once-daily, highly-selective cholesteryl ester transfer protein ("CETP") inhibitor, as a monotherapy and in fixed-dose combination with ezetimibe, as the preferred LDL-C lowering therapy to be used in patients at risk of CVD for whom existing therapies are not sufficiently effective or well-tolerated.

In July 2026, NewAmsterdam announced the Committee for Medicinal Products for Human Use $(CHMP)$ of the European Medicines Agency ("EMA") has adopted a positive opinion recommending marketing authorization for obicetrapib 10 mg monotherapy and 10 mg obicetrapib plus 10 mg ezetimibe fixed-dose combination ("FDC") for patients with primary hypercholesterolemia, both heterozygous familial ("HeFH") and non-familial or mixed dyslipidemia. A final decision from the European Commission is expected later this year.

In July 2026, NewAmsterdam presented four analyses from its Phase 3 BROADWAY program at the Alzheimer's Association International Conference $(AAIC)$ 2026, further characterizing the potential role of CETP inhibition in the prevention of early Alzheimer's disease. Highlights include:

   -- Prespecified analyses from the Phase 3 BROADWAY trial demonstrated 
      statistically significant reductions in plasma p-tau217 versus placebo. 
 
   -- Additional analyses provided further insights into Alzheimer's disease 
      biology and potential approaches to optimize future clinical development. 

In June 2026, NewAmsterdam presented four analyses at the National Lipid Association ("NLA") Scientific Sessions further characterizing obicetrapib's differentiated profile across atherosclerotic cardiovascular disease ("ASCVD") and heterozygous familial hypercholesterolemia ("HeFH"). The analyses included pooled Phase 3 BROADWAY and BROOKLYN data, real-world evidence from a large U.S. claims database and a cross-class review of contemporary cholesterol-lowering development programs. Highlights included:

   -- Two real-world analyses using the Komodo Claims and Research Dataset 
      highlighted persistent gaps in LDL-C goal attainment, treatment adherence, 
      and tolerability among high-risk patients receiving high-intensity 
      statins, reinforcing the need for additional well-tolerated LDL-C 
      lowering therapies. 
 
   -- A pooled mediation analysis of the Phase 3 BROADWAY and BROOKLYN trials 
      found that obicetrapib was observed to reduce major adverse 
      cardiovascular events ("MACE") by 23%, with reductions in LDL-C and 
      lipoprotein(a) jointly mediating 84.5% of this observed benefits. This 
      analysis further found that the observed MACE benefit was primarily 
      attributable to LDL-C lowering, with Lp(a) as an important additional 
      mediator. 
 
   -- A cross-class review of contemporary cholesterol-lowering development 
      programs suggest suggested non-CVOT MACE assessments may provide 
      meaningful insight into subsequent cardiovascular outcomes. 

NewAmsterdam plans to present additional analyses from the BROOKLYN and BROADWAY studies throughout 2026.

Upcoming Milestones and Ongoing Trials:

Following the successful completion and positive topline results of the Phase 3 BROADWAY, TANDEM, and BROOKLYN trials, NewAmsterdam plans to announce additional clinical data from these trials relating to obicetrapib and the fixed-dose combination ("FDC") of obicetrapib plus ezetimibe during 2026.

The following Phase 3 trials are currently ongoing:

   -- PREVAIL Phase 3 trial: PREVAIL is a cardiovascular outcomes trial 
      ("CVOT") evaluating obicetrapib in patients with a history of ASCVD, 
      whose LDL-C is not adequately controlled despite being on maximally 
      tolerated lipid-lowering therapy. NewAmsterdam completed enrollment of 
      over 9,500 patients in April 2024. 
 
   -- REMBRANDT Phase 3 trial: The REMBRANDT trial utilizes coronary computed 
      tomography angiography imaging to evaluate the effect of obicetrapib plus 
      ezetimibe FDC on coronary plaque burden. The placebo-controlled, 
      double-blind, randomized, Phase 3 trial is being conducted in adult 
      participants with high-risk ASCVD with evidence of coronary plaque who 
      are not adequately controlled by their maximally tolerated 
      lipid-modifying therapy, with the aim to assess the impact of the 
      obicetrapib 10 mg plus ezetimibe 10 mg FDC daily on lipid-rich coronary 
      plaque and arterial wall inflammation characteristics. In March 2026, the 
      trial completed enrollment of 323 patients. 
 
   -- RUBENS Phase 3 trial: Initiated in December 2025, the RUBENS trial is 
      evaluating obicetrapib alone or in combination with ezetimibe in patients 
      with type 2 diabetes or metabolic syndrome that require additional 
      lowering of LDL-C despite treatment with available therapy. The trial is 
      expected to enroll approximately 300 patients, with topline data expected 
      by year end 2026. 

Additionally, NewAmsterdam expects to initiate a new clinical trial evaluating obicetrapib for the prevention of early Alzheimer's disease in 2026.

Investor Day

NewAmsterdam will host an Investor Day event for analysts and investors, today, August 5, 2026, beginning at 9:00 a.m. ET in New York City.

A live webcast of the R&D event will be available and those who intend to join virtually can pre-register for the webcast through the link here. The live webcast and supporting presentation materials will be available on the Events section of the Investor Relations page of the NewAmsterdam website at ir.newamsterdampharma.com at the time of the live event. An archived replay will be available on the NewAmsterdam website. Please note advanced registration is required for in-person attendance.

First Quarter Financial Results

   -- Cash Position: As of June 30, 2026, NewAmsterdam recorded cash, cash 
      equivalents and marketable securities of $678.3 million, compared to 
      $728.9 million as of December 31, 2025. The decrease was primarily driven 
      by cash outflows related to research and development costs as the Company 
      continues development of obicetrapib and spending on selling, general and 
      administrative expenses to support the Company's ongoing operations, 
      partially offset by cash inflows from the exercise of options and 
      warrants. 
 
   -- Revenue: NewAmsterdam recognized $3.7 million in revenue for the quarter 
      ended June 30, 2026, compared to $19.1 million in the same period in 
      2025. Revenue for the three months ended June 30, 2025 was primarily 
      attributable to the recognition of $16.1 million of revenue related to 
      the second installment of development cost contributions under the 
      license agreement with Menarini. Revenue for the three months ended June 
      30, 2026 was related to Company's supply agreement with Menarini. 
 
   -- Research and Development ("R&D") Expenses: R&D expenses were $41.7 
      million in the quarter ended June 30, 2026, compared to $27.5 million for 
      the same period in 2025. This increase was primarily due to increases in 
      clinical expenses driven by the initiation of clinical trials and 
      increased costs associated with the progression of ongoing trials, and an 
      increase in personnel expenses. Share-based payment expenses included 
      within R&D expenses totaled $5.9 million in the quarter ended June 30, 
      2026, compared to $5.1 million in the same period in 2025. 
 
   -- Selling, General and Administrative ("SG&A") Expenses: SG&A expenses were 
      $26.9 million in the quarter ended June 30, 2026, compared to $27.3 
      million for the same period in 2025. This decrease was primarily due to 
      decreases in marketing and communication and intellectual property 
      expenses, partially offset by an increase in personnel expenses. 
      Share-based payment expenses included within SG&A expenses totaled $12.5 
      million in the quarter ended June 30, 2026, compared to $10.1 million in 
      the same period in 2025. 
 
   -- Net loss: Net loss for the quarter ended June 30, 2026, was $64.1 million, 
      compared to net loss of $17.4 million for the same period in 2025. The 
      individual components of the change are described above in addition to 
      interest income, a non-cash loss related to changes in the fair value of 
      our derivative warrant liabilities and foreign exchange losses. 

About Obicetrapib

Obicetrapib is a novel, oral, low-dose CETP inhibitor that NewAmsterdam is developing to overcome the limitations of current LDL-lowering treatments. In each of the Company's Phase 2 trials, ROSE2, TULIP, ROSE, and OCEAN, as well as the Company's Phase 3 BROOKLYN, BROADWAY and TANDEM trials, evaluating obicetrapib as monotherapy or combination therapy, the Company observed statistically significant LDL-lowering combined with a side effect profile similar to that of placebo. The Company commenced the Phase 3 PREVAIL cardiovascular outcomes trial in March 2022, which is designed to assess the potential of obicetrapib to reduce occurrences of MACE. The Company completed enrollment of PREVAIL in April 2024 and randomized over 9,500 patients. Commercialization rights of obicetrapib in Europe, either as a monotherapy or as part of a fixed-dose combination with ezetimibe, have been exclusively granted to the Menarini Group, an Italy-based, leading international pharmaceutical and diagnostics company.

About Cardiovascular Disease

Cardiovascular disease remains the leading cause of death globally, despite the availability of lipid-lowering therapies ("LLTs"). By 2050 more than 184 million U.S. adults are expected to be affected by CVD and hypertension, including 27 million with coronary heart disease and 19 million with stroke. In the United States from 2019 through 2022, CVD age-adjusted mortality rates increased by 9%, reversing the trend observed since 2010 and undoing nearly a decade of progress. Despite the availability of high-intensity statins and non-statin LLTs, LDL-C target level attainment remains low, contributing to residual cardiovascular risk, and underscoring a significant clinical need for improved therapeutic regimens. Even with 269 million LLT prescriptions written over the last 12 months, 30 million under-treated US adults are not at their risk-based LDL-C goal, of which 13 million have ASCVD. Less than 1 in 4 patients with ASCVD achieve an LDL-C goal of less than 70 mg/dL and only 10% of very high risk ASCVD patients achieve the goal below 55 mg/dL. In addition to the 30 million under-treated U.S. adults, there are 10 million patients diagnosed with elevated LDL-C who are not taking any LLTs including statins. Beyond LDL-C, additional factors are at play, such as lifestyle choices, tobacco use, and obesity, as well as inflammation, thrombosis, triglyceride levels, elevated Lp(a) levels, and type 2 diabetes.

Alzheimer's Analysis

In BROADWAY, a pre-specified analysis was designed to assess plasma biomarkers of Alzheimer's disease ("AD") in patients enrolled in the BROADWAY trial and evaluated the effects of longer duration of therapy (12 months) with a prespecified ApoE population, based on phenotypic analysis. The analysis included 1,535 patients, including 367 ApoE4 carriers (ApoE3/E4 or ApoE4/E4), whose ApoE status was able to be determined. Because this analysis was based on a subset of patients from BROADWAY (which was designed to evaluate LDL-C reductions in an ASCVD and/or HeFH population), the AD analysis was not controlled for baseline differences between the treatment and placebo populations, but statistical analyses were adjusted for baseline biomarker values and age. The absolute and percent change over 12 months in p-tau217, a key biomarker of AD pathology, were measured among patients with baseline and end of study datapoints above the lower limit of quantitation. Additional outcome measures included NFL, GFAP, p-tau181, and A<BETA>42/40 ratio absolute and percent change over 12 months. NewAmsterdam observed statistically significant lower absolute changes in p-tau217 compared to placebo over 12 months in both the full analysis set (p=0.002; n= 1,535) and in ApoE4 carriers (p=0.02; n=367) as well as favorable trends in the other AD biomarkers. Although a safety analysis was not performed in the AD analysis population, in BROADWAY obicetrapib was observed to be well-tolerated, with safety results comparable to placebo.

About NewAmsterdam

NewAmsterdam Pharma (Nasdaq: NAMS) is a late-stage biopharmaceutical company whose mission is to improve patient care in populations with metabolic diseases where currently approved therapies have not been adequate or well tolerated. We seek to fill a significant unmet need for a safe, well-tolerated and convenient therapy that lowers LDL-C while advancing innovation beyond a single marker to better address cardiovascular risk. In multiple phase 3 trials, NewAmsterdam is investigating obicetrapib, an oral, low-dose and once-daily CETP inhibitor, alone or as a fixed-dose combination with ezetimibe, as LDL-C lowering therapies to be used as an adjunct to statin therapy for patients at risk of CVD with elevated LDL-C, for whom existing therapies are not sufficiently effective or well tolerated.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995 and are subject to the "safe harbor" provisions created thereunder. All statements that are not historical facts are hereby identified as forwarding-looking statements for this purposes and include, among others, statements relating to: the Company's intention to conduct the PREVAIL interim analysis and its expectations regarding the timing of the interim analysis and when the result of the interim analysis may be announced; expectations regarding the timing of potential approval decisions from the European Commission for obicetrapib and the FDC of obicetrapib plus ezetimibe; the Company's expectations for total enrollment figures for and topline data from the RUBENS trial by year-end 2026; the initiation of a new clinical trial evaluating obicetrapib in early Alzheimer's disease in 2026; the therapeutic potential of the Company's product candidates; the Company's other plans regarding and the timing for commencing trials, enrolling patients and completing trials, and the timing and forums for announcing data; expected milestones and anticipated progress toward such milestones; and other statements regarding the Company's future operations, prospects, objectives, strategies and other future events.

The Company may not actually achieve the plans, intentions or expectations disclosed in these forward-looking statements, and you should not place undue reliance on these forward-looking statements. These forward-looking statements are based upon management's current expectations and assumptions. Actual results or events could differ materially and adversely from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various risks, uncertainties and other factors, including, among others: uncertainties and delays regarding the initiation, enrollment and completion of the Company's clinical trials; uncertainties regarding the result of the PREVAIL interim analysis; uncertainties regarding the outcome of the Company's clinical trials, and whether such outcomes will be adequate to support regulatory review and approval of its product candidates; whether topline, initial or preliminary results, trends or analyses from a particular clinical trial will be predictive of the final results of that trial and whether results of early clinical trials and analyses will be indicative of the results of later clinical trials and analyses, or whether projections regarding clinical outcomes will reflect actual results in future clinical trials or clinical use of the Company's product candidates; the potential for varying interpretation of the results of clinical trials and analyses; risks related to the Company's ability to achieve its business plans, objectives and milestones, including approval of the Company's product candidates and potential commercialization; challenges inherent to the launch of new drug products, if approved; risks related to the Company's reliance on third parties; unanticipated costs and expenses impacting the Company's cash runway; the Company's ability to continue to source the raw materials for its product candidates and ensure adequate supply of product for clinical trials and, if approved, commercialization; the impact of competing product candidates on the Company's business; risks and uncertainties relating to intellectual property and regulatory exclusivities; changes in domestic and foreign business, market, financial, political, and legal conditions; and other important factors, any of which could cause the Company's actual results to differ from those contained in the forward-looking statements, that are described in greater detail in the sections entitled "Risk Factors" in the Company's Annual Report on Form 10-K filed with the Securities and Exchange Commission ("SEC") on February 18, 2026 and in its Quarterly Report on Form 10-Q filed with the SEC on August 5, 2026, as well as in other filings the Company may make with the SEC in the future, which are available at www.sec.gov. Any forward-looking statements contained in this press release speak only as of the date of this press release, and the Company expressly disclaims any obligation to update any forward-looking statements contained herein, whether because of new information, future events, changed circumstances or otherwise, except as otherwise required by law.

Company Contact

Matthew Philippe

P: 1-917-882-7512

matthew.philippe@newamsterdampharma.com

Media Contact

Real Chemistry on behalf of NewAmsterdam

Christian Edgington

P: 1-513-310-6410

cedgington@realchemistry.com

Investor Contact

Precision AQ on behalf of NewAmsterdam

Austin Murtagh

P: 1-212-698-8696

austin.murtagh@precisionaq.com

 
                   NewAmsterdam Pharma Company N.V. 
                 Condensed Consolidated Balance Sheet 
                              (Unaudited) 
                                           June 30,    December 31, 
                                             2026          2025 
                                          ----------   ------------ 
(In thousands of USD) 
Assets 
  Current assets: 
  Cash and cash equivalents                  424,151        490,002 
  Prepayments and other receivables           23,996         38,138 
  Marketable securities, current             209,703        146,239 
  Restricted cash                              1,357          1,321 
                                           ---------   ------------ 
   Total current assets                      659,207        675,700 
Marketable securities, net of current 
 portion                                      44,409         92,609 
Property, plant and equipment, net               411            383 
Operating right of use asset                      82            185 
Intangible assets                                343            407 
   Total assets                              704,452        769,284 
                                           =========   ============ 
Liabilities and Shareholders' Equity 
Current liabilities: 
  Accounts payable                             5,422          8,970 
  Accrued expenses and other current 
   liabilities                                10,277         15,422 
  Deferred revenue, current                    2,797          3,987 
  Lease liability, current                        26            136 
  Derivative warrant liabilities              54,452         57,272 
                                           ---------   ------------ 
   Total current liabilities                  72,974         85,787 
Lease liability, net of current portion           56             66 
                                           ---------   ------------ 
   Total liabilities                          73,030         85,853 
                                           =========   ============ 
Commitments and contingencies (Note 12) 
Shareholders' Equity: 
Ordinary shares, EUR0.12 par value; 
 400,000,000 shares authorized; 
 117,651,697 and 114,399,326 shares 
 issued and outstanding as at June 30, 
 2026 and December 31, 2025, 
 respectively                                 14,735         14,278 
Additional paid-in capital                 1,487,792      1,426,750 
Accumulated loss                            (874,966)      (762,390) 
Accumulated other comprehensive income         3,861          4,793 
                                           ---------   ------------ 
Total shareholders' equity                   631,422        683,431 
                                           ---------   ------------ 
Total liabilities and shareholders' 
 equity                                      704,452        769,284 
                                           =========   ============ 
 
 
NewAmsterdam Pharma Company N.V. 
 Condensed Consolidated Statements of Operations and 
 Comprehensive Loss 
 (Unaudited) 
                       For the three 
                       months ended June    For the six months 
                       30,                    ended June 30, 
                         2026      2025       2026       2025 
                       --------   -------   --------   -------- 
(In thousands of USD, 
except per share 
amounts) 
Revenue                   3,701    19,145      6,741     22,123 
Operating expenses: 
  Research and 
   development 
   expenses              41,673    27,516     79,682     72,267 
  Selling, general and 
   administrative 
   expenses              26,892    27,264     50,343     54,416 
   Total operating 
    expenses             68,565    54,780    130,025    126,683 
                        -------   -------   --------   -------- 
Operating loss          (64,864)  (35,635)  (123,284)  (104,560) 
Other income 
(expense): 
  Interest income         5,810     7,055     11,460     14,406 
  Fair value change -- 
   earnout                   --        --         --      3,992 
  Fair value change -- 
   warrants              (4,555)    2,590      1,387     16,352 
  Foreign exchange 
   gains/(losses)          (526)    8,626     (2,139)    12,919 
Loss before tax         (64,135)  (17,364)  (112,576)   (56,891) 
  Income tax expense         --        --         --         -- 
Loss for the period     (64,135)  (17,364)  (112,576)   (56,891) 
Other comprehensive 
income/(loss) 
  Unrealized 
   gain/(loss) on 
   available-for-sale 
   securities, net of 
   tax                     (360)     (107)      (932)      (140) 
Total comprehensive 
 loss for the period, 
 net of tax             (64,495)  (17,471)  (113,508)   (57,031) 
                        -------   -------   --------   -------- 
 
 
                                NewAmsterdam Pharma Company N.V. 
                        Condensed Consolidated Statements of Shareholders' 
                                              Equity 
                                           (Unaudited) 
(In thousands                                                     Accumulated 
of USD, except                        Additional                     Other           Total 
share                                  Paid-In     Accumulated   Comprehensive   Shareholders' 
amounts)           Shares     Amount   Capital        Loss          Income          Equity 
                ------------  ------  ----------   -----------   -------------   ------------- 
Balance at 
 December 31, 
 2024            108,064,340  13,444   1,298,160      (558,571)          4,467         757,500 
                 ===========  ======  ==========   ===========   =============   ============= 
Issuance of 
 Earnout 
 Shares            1,743,136     226      40,581            --              --          40,807 
Exercise of 
 Pre-Funded 
 Warrants          1,293,938     162        (162)           --              --              -- 
Exercise of 
 warrants             15,942       2         410            --              --             412 
Exercise of 
 stock options       909,140     116       2,875            --              --           2,991 
Vesting of RSUs      142,795      18         (18)           --              --              -- 
Share-based 
 compensation             --      --      15,213            --              --          15,213 
Total loss and 
 comprehensive 
 loss for the 
 period                   --      --          --       (39,527)            (33)        (39,560) 
                 -----------  ------  ----------   -----------   -------------   ------------- 
As at March 31, 
 2025            112,169,291  13,968   1,357,059      (598,098)          4,434         777,363 
                 ===========  ======  ==========   ===========   =============   ============= 
Exercise of 
 warrants                100      --           2            --              --               2 
Exercise of 
 stock options       340,317      46       3,378            --              --           3,424 
Vesting of 
RSUs                     206      --          --                                            -- 
Share-based 
 compensation             --      --      15,179            --              --          15,179 
Total loss and 
 comprehensive 
 loss for the 
 period                   --      --          --       (17,364)           (107)        (17,471) 
                 -----------  ------  ----------   -----------   -------------   ------------- 
As at June 30, 
 2025            112,509,914  14,014   1,375,618      (615,462)          4,327         778,497 
                 ===========  ======  ==========   ===========   =============   ============= 
 
Balance at 
 December 31, 
 2025            114,399,326  14,278   1,426,750      (762,390)          4,793         683,431 
                 ===========  ======  ==========   ===========   =============   ============= 
Exercise of 
 warrants             56,619       8       1,745            --              --           1,753 
Exercise of 
 stock options     1,971,548     278      10,771            --              --          11,049 
Vesting of RSUs      214,163      30         (30)           --              --              -- 
Share-based 
 compensation             --      --      18,002            --              --          18,002 
Total loss and 
 comprehensive 
 loss for the 
 period                   --      --          --       (48,441)           (572)        (49,013) 
                 -----------  ------  ----------   -----------   -------------   ------------- 
As at March 31, 
 2026            116,641,656  14,594   1,457,238      (810,831)          4,221         665,222 
                 ===========  ======  ==========   ===========   =============   ============= 
Exercise of 
 warrants             12,752       2         476            --              --             478 
Exercise of 
 stock options       971,668     135      11,701            --              --          11,836 
Vesting of RSUs       25,621       4          (4)           --              --              -- 
Share-based 
 compensation             --      --      18,381            --              --          18,381 
Total loss and 
 comprehensive 
 loss for the 
 period                   --      --          --       (64,135)           (360)        (64,495) 
                 -----------  ------  ----------   -----------   -------------   ------------- 
As at June 30, 
 2026            117,651,697  14,735   1,487,792      (874,966)          3,861         631,422 
                 ===========  ======  ==========   ===========   =============   ============= 
 
 
                  NewAmsterdam Pharma Company N.V. 
           Condensed Consolidated Statements of Cash Flows 
                             (Unaudited) 
                                 For the six months ended June 30, 
                                     2026                  2025 
                               -----------------      --------------- 
(In thousands of USD) 
Operating activities: 
Loss for the period                     (112,576)             (56,891) 
Non-cash adjustments to 
reconcile loss for the period 
to net cash flows: 
   Depreciation and 
    amortization                             121                   97 
   Non-cash rent expense                     (13)                   3 
   Fair value change - 
    derivative earnout and 
    warrants                              (1,387)             (20,344) 
   Loss on disposal of 
   property, plant and 
   equipment                                  18                   -- 
   Foreign exchange 
    (gains)/losses                         2,139              (12,919) 
   Amortization of 
    premium/discount on 
    available-for-sale debt 
    securities                               (42)                (985) 
   Share-based compensation               36,383               30,392 
Changes in working capital: 
   Changes in prepayments and 
    other receivables                     15,354               (5,830) 
   Changes in accounts payable            (3,480)               1,860 
   Changes in accrued expenses 
    and other current 
    liabilities                           (5,145)              (3,514) 
   Changes in deferred revenue            (1,190)              (6,008) 
                                ----------------      --------------- 
Net cash used in operating 
 activities                              (69,818)             (74,139) 
                                ----------------      --------------- 
Investing activities: 
   Purchase of property, plant 
    and equipment, including 
    internal use software                   (118)                (104) 
   Maturities of marketable 
    securities                            97,500               37,163 
   Purchases of marketable 
    securities                          (113,653)            (193,340) 
                                ----------------      --------------- 
Net cash used in investing 
 activities                              (16,271)            (156,281) 
                                ----------------      --------------- 
Financing activities: 
   Transaction costs on 
    December 2024 issue of 
    Ordinary Shares and 
    Pre-Funded Warrants                       --               (1,586) 
   Proceeds from exercise of 
    warrants                                 798                  184 
   Proceeds from exercise of 
    options                               21,308               11,346 
                                ----------------      --------------- 
Net cash provided by financing 
 activities                               22,106                9,944 
                                ----------------      --------------- 
Net change in cash, cash 
 equivalents and restricted 
 cash                                    (63,983)            (220,476) 
Foreign exchange differences              (1,832)              12,597 
Cash, cash equivalents and 
 restricted cash at the 
 beginning of the period                 491,323              771,743 
                                ----------------      --------------- 
Cash, cash equivalents and 
 restricted cash at the end of 
 the period                              425,508              563,864 
                                ================      =============== 
Noncash financing and 
investing activities 
   Issuance of earnout shares                 --               40,807 
 
Reconciliation of cash, cash 
equivalents and restricted 
cash to the Condensed 
Consolidated Balance Sheets 
   Cash and cash equivalents             424,151              563,864 
   Restricted cash                         1,357                   -- 
                                ----------------      --------------- 
                                         425,508              563,864 
 =============================  ================      =============== 
 

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