SAN DIEGO, Aug. 28, 2026 (GLOBE NEWSWIRE) -- iBio, Inc. $(IBIO)$, a clinical-stage biotechnology company developing long-acting antibody therapeutics for obesity, cardiometabolic and cardiopulmonary diseases, today announced its financial results for the fiscal year ended June 30, 2026, and provided a corporate update on its progress.
"Fiscal year 2026 was a transformative year for iBio, most importantly marked by our transition to a clinical-stage company with the initiation of the Phase 1 clinical trial of IBIO-600, a potentially best-in-class, long-acting anti-myostatin monoclonal antibody designed to preserve muscle and improve body composition," said Martin Brenner, Ph.D., DVM, Chief Executive Officer and Chief Scientific Officer of iBio. "Additional highlights came from our IBIO-610 program, where we presented preclinical data supporting its potential for fat-selective weight loss, complementing with current GLP-1 therapies by increasing fat loss while preserving lean mass, and to reduce weight regain following GLP-1 discontinuation. We are excited to build on this progress as we continue advancing our pipeline and working toward our mission of delivering transformative treatments to patients."
Progress on Obesity and Cardiometabolic Pipeline
-- Advanced IBIO-610, iBio's long-acting Activin E antibody, into
IND-enabling studies. In obese non-human primates, a single dose produced
near-complete suppression of active Activin E for up to eight weeks and
demonstrated a prolonged pharmacokinetic profile supporting the potential
for infrequent dosing. Additional preclinical studies in rodents
demonstrated fat-selective weight loss, additive weight loss and enhanced
body-composition effects in combination with semaglutide, and prevention
of weight regain following GLP-1 discontinuation. These data support
IBIO-610's potential as a differentiated treatment for obesity and
related cardiometabolic diseases.
-- Advanced IBIO-600, iBio's long-acting myostatin antibody, through the
single ascending dose portion of its first-in-human Phase 1 clinical
trial, dosing 31 of the 32 planned participants across all four planned
cohorts with no safety findings identified that precluded dose
escalation. IBIO-600 is being developed to preserve muscle and improve
body composition, including as a potential complement to GLP-1-based
therapies. iBio is now preparing to advance IBIO-600 into the multiple
ascending dose escalation portion of the clinical trial.
-- Advanced IBIO-800, iBio's myostatin × Activin A bispecific antibody,
into IND-enabling development following selection of a development
candidate. iBio initiated CMC and IND-enabling nonclinical development
and presented preclinical data supporting its potential to preserve and
increase muscle and address cardiopulmonary disease, with an initial
focus on pulmonary hypertension associated with heart failure with
preserved ejection fraction (PH-HFpEF).
-- In-licensed all rights to AstralBio's amylin receptor antibody program
that includes a portfolio of next-generation antibody agonists designed
to achieve differentiated receptor pharmacology. The program includes
selective AMY1 and AMY3 receptor agonists, selective amylin receptor
agonists targeting both AMY1 and AMY3, and dual amylin and calcitonin
receptor agonists. Candidates are advancing through preclinical
characterization to identify the pharmacologic profiles best suited to
the treatment of obesity and metabolic disease.
Corporate Developments
Financing and Capital Resources
-- Closed a public offering in August 2025 for total potential gross
proceeds of up to $100 million (assuming the exercise of all of the
warrants sold in the offering in full for cash), led by Balyasny Asset
Management with participation from Cormorant Asset Management, Adage
Capital Partners, Ally Bridge Group, Marshall Wace, Coastlands Capital,
SilverArc Capital Management, Vestal Point Capital, and Ausangate
Capital.
-- Closed a $26 million private placement in January 2026 with
healthcare-focused institutional investors led by Frazier Life Sciences,
along with participation from other existing investors.
-- Entered into an Open Market Sale AgreementSM$(TM)$ with Jefferies LLC
providing for the sale, from time to time, of up to $100 million of
shares of iBio common stock.
Leadership Updates
-- Strengthened the Board with the appointment of Elizabeth Stoner, M.D.,
who brings deep biotechnology industry experience and expertise in
capital markets and clinical-stage drug development.
-- Appointed Molly Carr, M.D. as iBio's Chief Medical Officer, bringing more
than 30 years of clinical, academic and biopharmaceutical experience in
endocrinology and metabolic diseases to lead iBio's global clinical
strategy, medical affairs and regulatory initiatives.
"In the last fiscal year, we paired significant scientific progress with disciplined financial execution, substantially strengthening iBio's balance sheet as we advanced our pipeline into clinical development," said Felipe Duran, Chief Financial Officer. "Our successful financings, which extended our cash runway into fiscal year 2028, together with the addition of highly experienced leaders to our Board and management team, provide a strong foundation to execute on our clinical programs and translate continued scientific progress into meaningful value for patients and shareholders."
Financial Results:
Revenues for the fiscal year ended June 30, 2026, were approximately $0.1 million, a decrease of $0.3 million over the $0.4 million in revenue for the fiscal year 2025.
Research and Development ("R&D") expenses for the fiscal year ended June 30, 2026, and June 30, 2025, were approximately $19.6 million and $8.3 million, respectively, an increase of approximately $11.3 million. The increase in R&D expenses is mainly due to increased spending of approximately $8.4 million on consultants and outside services supporting our R&D efforts, including NHP studies and CMC activities, for iBio's IBIO-610 and IBIO-600 programs and other preclinical pipeline assets, and a $2.5 million development milestone.
General and Administrative expenses for the fiscal year ended June 30, 2026, and June 30, 2025, were approximately $10.6 million and $10.7 million, respectively, a decrease of approximately $0.1 million.
Impairment of Indefinite-Lived Intangible Assets for the fiscal year ended June 30, 2026, was approximately $5.0 million and was attributable to the impairment of our indefinite-lived intangible asset, IBIO-101. No impairments of indefinite-lived intangible assets were recorded for the fiscal year ended June 30, 2025.
iBio held cash and cash equivalents and investments in debt securities of approximately $88.0 million as of June 30, 2026.
About iBio, Inc.
iBio (Nasdaq: IBIO) is a clinical-stage biotechnology developing long-acting antibody therapeutics for obesity, cardiometabolic and cardiopulmonary diseases, cancer, and other hard-to-treat diseases. Combining advanced antibody engineering with AI-driven discovery, iBio is advancing a differentiated pipeline designed to deliver sustained therapeutic effects and address significant unmet medical needs. iBio's mission is to transform drug discovery, accelerate development timelines, and unlock new possibilities in precision medicine.
For more information, visit www.ibioinc.com or follow us on LinkedIn.
Forward-Looking Statements
Certain statements in this press release constitute "forward-looking statements" within the meaning of the federal securities laws. Words such as "may," "might," "will," "should," "believe," "expect," "anticipate," "estimate," "continue," "predict," "forecast," "project," "plan," "intend" or similar expressions, or statements regarding intent, belief, or current expectations, are forward-looking statements. These forward-looking statements are based upon current estimates and assumptions and include statements regarding IBIO-600 potentially being a best-in-class, long-acting anti-myostatin monoclonal antibody to preserve muscle and improve body composition; IBIO-610's potential for fat-selective weight loss, complementing GLP-1 therapy by increasing fat loss while preserving lean mass, and reducing weight regain following GLP-1 discontinuation; iBio continuing to advance its pipeline and working toward its mission of delivering transformative treatments to patients; the potential for infrequent dosing of IBIO-610, iBio's long-acting Activin E antibody; preclinical studies of IBIO-610 supporting its potential as a differentiated treatment for obesity and related cardiometabolic diseases; the four planned cohorts of the IBIO-600 Phase 1 clinical trial; the potential to move IBIO-600 into multiple ascending dose portion of the clinical trial; the potential of IBIO-600 to preserve muscle and improve body composition, including as a potential complement to GLP-1-based therapies; the potential of IBIO-800 to preserve and increase muscle and address cardiopulmonary disease; the assumed exercise of all of the warrants sold in the August 2025 public offering in full for cash; Dr. Carr leading the company's global clinical strategy, medical affairs, and regulatory initiatives; the company advancing its obesity and cardiometabolic pipeline toward and into clinical development; the addition of highly experienced leaders to iBio's Board and management team, together with its successful financings, providing a strong foundation to continue translating scientific progress into meaningful clinical and corporate value; iBio's differentiated pipeline delivering sustained therapeutic effects and addressing significant unmet medical needs; and iBio's ability to transform drug discovery,
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