Race Oncology reported preclinical findings on its lead compound, bisantrene, demonstrating its efficacy in treating multiple myeloma when used alone and in combination with the proteasome inhibitor carfilzomib.
The preclinical studies showed that bisantrene effectively killed human multiple myeloma cells at clinically relevant concentrations in cell culture and mouse models.
When combined with carfilzomib, the treatment slowed disease progression more significantly than bisantrene alone.
"The potential for using bisantrene to not only better treat multiple myeloma but also protect patients from the heart damage caused by carfilzomib is worthy of further investigation," said Daniel Tillett, CEO of Race Oncology.
Race Oncology plans to advance further preclinical studies to understand the mechanisms behind the observed therapeutic effects and cardioprotection.
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