The stock market rally is in its most fragile state in months ahead of Wall Street's busiest week of the summer.Earnings from four of the Magnificent Seven tech stocks — Amazon, Meta, Microsoft, and Apple — could change that. But as the sell-off after Alphabet and Tesla earnings showed in the prior week, it's been a tough season to impress investors with earnings.The best-performing concepts is Gene editing.
Considering the different perceptions of the stock, this time TigerPicks chose $Beam Therapeutics, Inc.(BEAM)$ to have a fundamental highlight to help users understand it better.
$Beam Therapeutics, Inc.(BEAM)$
Beam Therapeutics Inc., a biotechnology company, engages in the development of precision genetic medicines for patients suffering from serious diseases in the United States.
It develops BEAM-101 for the treatment of sickle cell disease or beta-thalassemia; and BEAM-302, a liver-targeting LNP formulation to treat severe alpha-1 antitrypsin deficiency; BEAM-201, an anti-CD7 CAR-T product candidate, which is in Phase 1/2 clinical trials for the treatment of refractory T-cell acute lymphoblastic leukemia/T cell lymphoblastic lymphoma; and BEAM-301, a liver-targeting LNP formulation for the treatment of glycogen storage disease 1a.
The company has research collaboration agreement with Pfizer Inc., focus on in vivo base editing programs for targets rare genetic diseases of the liver, muscle, and central nervous system; Apellis Pharmaceuticals to conduct preclinical research on target specific genes within the complement system in various organs, including the eye, liver, and brain; Verve Therapeutics, Inc., for cardiovascular disease treatments; Sana Biotechnology, Inc., to research, develop, and commercialize rights to CRISPR Cas12b for cell therapy programs; and Orbital Therapeutics design RNA for the prevention, treatment or diagnosis of human disease.
The concept of dna the study of molecules .
Our last look at $Beam Therapeutics, Inc.(BEAM)$ occurred in February 2023. We concluded that article saying the stock at most merit a small "watch item" position for speculative investors. The shares have fallen since then, as they have for most gene editing concerns. This is not that surprising given that most paradigm shifts in biotech (EX, stem cell therapy, CAR-T) also seem to take much longer to develop than initially hoped. Given it has been nearly a year and a half since we peaked in at this developmental firm, it seems a good time to circle back to Beam Therapeutics. An updated analysis follows below.
Base Editing
Beam Therapeutics is headquartered in Cambridge, MA, right outside of Boston. The company is focused on developing precision genetic medicines through base editing. The stock currently trades for just over $23.00 a share and sports an approximate market capitalization of $1.85 billion.
Base Editing
Pipeline Developments:
Partnerships
The company has a significant collaboration partnership with drug giant $Pfizer(PFE)$ that provided a $300 million upfront payment when it was signed early in 2022. The company has other less lucrative partnerships and in October 2023 sold its opt-in rights to $Verve Therapeutics(VERV)$ gene therapy programs to $Eli Lilly(LLY)$ for a potential $600 million, of which Beam received one third upfront payment and a $50 million equity investment.
Pipeline
The company is advancing several "shots on goal" within its pipeline. That said, the pipeline remains quite early stage. In 2024, Beam Therapeutics has several milestones on the horizon. However, they involve kicking off early-stage studies, one IND application and disclosing data from early-stage trials.
Anticipated 2024 Milestones
The company's most lucrative potential assets remain BEAM-101 targeting Sickle Cell Disease and BEAM-302 being evaluated as a potential curative therapy for Alpha-1 Antitrypsin Deficiency, and a Phase 1/2 study is scheduled to kick off before yearend for that asset. The expansion cohort from a Phase 1/2 Trial for BEAM-101 was recently initiated as well.
Beam-101
BEAM-302
Analyst Commentary & Balance Sheet:
Since Beam Therapeutics posted its latest quarterly results on May 7th, the view from the analyst community is quite split. Five analyst firms, including JPMorgan and Wells Fargo, have reissued/assigned Buy ratings on Beam Therapeutics. Price targets proffered range from $45 to $56 a share. Meanwhile, RBC Capital ($35 price target), Leerink Partners ($27 price target), Barclays ($33 price target, down from $42 previously) and Canaccord Genuity ($42 price target) have all maintained Hold ratings on the stock.
Company officers have sold just under $7 million in the stock collectively so far in 2024 with the CEO being responsible for approximately for two thirds of those disposals. A beneficial owner also reduced their stake in the firm by just under $28 million worth of equity in February of this year. Beam Therapeutics ended the first quarter with approximately $1.1 billion in cash and marketable securities on its balance sheet after posting a net loss of $98.7 million for the quarter. Management has stated this is sufficient to fund all planned operations into 2027.
Conclusion:
Stock Chart
Beam Therapeutics remains a somewhat intriguing play in the gene editing space. Analyst opinion remains mixed on the company's prospects, but Wells Fargo did put the company on its fairly lengthy potential buyout "list" in May. The stock is trading right at five-year support levels.
HAE population
That said, $Intellia Therapeutics(NTLA)$ which also appeared on Fargo's May potential acquisition list, remains my favorite stock in the gene editing space. The company has a potential curative gene therapy for HAE that could be approved by 2027, and I last highlighted this name in late February.
Pipeline
Beam Therapeutics Inc. has a cash-rich balance sheet, but is burning cash at a prodigious quarterly rate, advancing several candidates. The challenge is that development is proceeding at a somewhat glacial pace, and there hasn't been that much progress (see above) from our last look at Beam Therapeutics. Of note again, this is not unusual in the gene editing space. I would become more interested in BEAM once the company had advanced at least one candidate into pivotal trials. Until then, the stock continues to merit only a small holding for patient and risk-tolerant investors.
Stock Price Forecast:
Here are the target price forecasts for the next 12 months from analysts.
Based on 11 Wall Street analysts offering 12 month price targets for Beam Therapeutics in the last 3 months. The average price target is $45.56 with a high forecast of $80.00 and a low forecast of $27.00. The average price target represents a 37.48% change from the last price of $33.14.
Resource:
https://seekingalpha.com/article/4701899-beam-therapeutics-slow-developmental-progress-but-promising-potential
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