J.&J. Pauses Production of Its Covid Vaccine Despite Persistent Need

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J.&J. Pauses Production of Its Covid Vaccine Despite Persistent Need

The New York Times2022-02-09

A crucial Johnson & Johnson plant has stopped making its Covid vaccine, though the company says it has millions of doses in inventory.Johnson & Johnson quietly stopped making batches of its vaccine at...

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benjam
·2022-02-09
One wonders how long the delay will last.
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PBL77
·2022-02-09
[Cool]
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AiChee
·2022-02-09
👍
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newminted
·2022-02-09
Ok
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GeraldLee
·2022-02-09
세상에! 어떻게??
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Ku9787
·2022-02-09
Hmm
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Jloong
·2022-02-09
U
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Pauses Production of Its Covid Vaccine Despite Persistent Need\n</h2>\n\n<h4 class=\"meta\">\n\n\n2022-02-09 09:02 GMT+8&nbsp;&nbsp;&nbsp;<a href=https://www.nytimes.com/2022/02/08/business/johnson-johnson-covid-vaccine.html><strong>The New York Times</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>A crucial Johnson & Johnson plant has stopped making its Covid vaccine, though the company says it has millions of doses in inventory.Johnson & Johnson quietly stopped making batches of its vaccine at...</p>\n\n<a href=\"https://www.nytimes.com/2022/02/08/business/johnson-johnson-covid-vaccine.html\">Source Link</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"JNJ","symbol_name":"强生","start_time":0,"source_url":"https://www.nytimes.com/2022/02/08/business/johnson-johnson-covid-vaccine.html","article_id":"1147805649","we_media_id":null,"thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=1147805649","pubTimestamp":1644368543,"columns":[],"sourceInfo":{"source_id":"lsy1608616134662","name":"The New York Times"},"weMediaInfo":null,"summary":"A crucial Johnson & Johnson plant has stopped making its Covid vaccine, though the company says it h","collect":0,"end_time":0,"defaultTopTitle":"nytimes.com","property":[],"viewcount":null,"language":"en","relate_stocks":{"JNJ":"强生"},"translate_title":"J.&J。尽管持续需要，但暂停Covid疫苗的生产","themeId":"","isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"JNJ":0.9},"content_text":"A crucial Johnson & Johnson plant has stopped making its Covid vaccine, though the company says it has millions of doses in inventory.Johnson & Johnson quietly stopped making batches of its vaccine at its facility in the Dutch city of Leiden.Credit...Rob Engelaar/EPAJohnson & Johnson’s easy-to-deliver Covid-19 shot is the vaccine of choice for much of the developing world.Yet the American company, which has already fallen far behind on its deliveries to poorer countries, late last year quietly shut down the only plant making usable batches of the vaccine, according to people familiar with the decision.The facility, in the Dutch city of Leiden, has instead been making an experimental but potentially more profitable vaccine to protect against an unrelated virus.The halt is temporary — the Leiden plant is expected to start churning out the Covid vaccine again after a pause of a few months — and it is not clear whether it has had an impact on vaccine supplies yet, thanks to stockpiles.But over the next several months, the interruption has the potential to reduce the supply of Johnson & Johnson’s Covid vaccine by a few hundred million doses, according to one of the people familiar with the decision. Other facilities have been hired to produce the vaccine but either aren’t up and running yet or haven’t received regulatory approval to send what they’re making to be bottled.Inside Johnson & Johnson’s executive suites, the decision to suspend production at Leiden prompted concerns that it would impair the company’s ability to deliver on its vaccine commitments to the developing world.Johnson & Johnson’s move also blindsided officials at two of the company’s most important customers: the African Union and Covax, the clearinghouse responsible for getting vaccines to poor countries. Leaders of those organizations learned of the halt in production from New York Times reporters.“This is not the time to be switching production lines of anything, when the lives of people across the developing world hang in the balance,” said Dr. Ayoade Alakija, a co-head of the African Union’s vaccine-delivery program.Jake Sargent, a spokesman for Johnson & Johnson, said in an email that the company was “focused on ensuring our vaccine is available where people are in need” and that its global production network “is working day and night” to help fight the pandemic.He said the company was continuing to deliver batches of the vaccine to facilities that bottled and packaged doses. He also said Johnson & Johnson had millions of finished doses in inventory.Johnson & Johnson’s Covid vaccine, initially billed as a single shot, fell out of favor in the United States and other wealthy countries in part because of its link to a rare but dangerous blood-clotting disorder. Studies have found that it performs worse by some measures than the shots from Pfizer and Moderna.But poorer countries remain reliant on Johnson & Johnson’s vaccine, which does not require ultracold refrigeration. It has been shown to provide strong and long-lasting protection against severe disease across variants,including Omicron, when given as a two-shot regimen. As a single shot, the vaccine is less expensive and relatively easy to give to hard-to-reach populations.“In many low- and middle-income countries, our vaccine is the most important and sometimes only option,” Dr. Penny Heaton, a Johnson & Johnson executive,saidin December at a meeting of experts advising the U.S. government on vaccines. She added, “The world is depending on us.”Lower-income countries now have more vaccine options than at any previous point in the pandemic, and the impact of pausing production at the Leiden plant is therefore less severe than it might have been in the past. Some African governments have asked vaccine manufacturers to pause shipments until the countries use what they have on hand. Companies have cited that as evidence that they are providing plenty of vaccines to poorer countries.But the reality is more complicated.Only about 11 percent of Africans have been fully vaccinated (and few have received boosters). Many countries lack the infrastructure — medical personnel, storage facilities and transportation — to quickly inoculate their populations. They don’t need a huge pile of vaccines all at once; they need a steady and predictable supply over many months.Johnson & Johnson’s Covid vaccine has been in heavy use in the developing world.Credit...Leo Correa/Associated PressAs recently as last summer, Johnson & Johnson hadprojectedthat it would deliver one billion doses of its Covid vaccine in 2021. The company badly missed that target, releasing roughly 400 million doses, according to a person familiar with the company’s vaccine production.Mr. Sargent said the company was continuing to fulfill its contractual obligations to the African Union, which has ordered vaccines on behalf of dozens of countries in Africa and the Caribbean, and to Covax, which buys vaccines for scores of low-income governments.But Johnson & Johnson failed to deliver anywhere near as many doses to Covax as it planned. The company said in May that it “aimed to supply” up to 200 million vaccine doses to Covax by the end of last year. Covax got only four million; another 151,000 arrived last month, according to Gavi, the main nonprofit that runs Covax. (Wealthy countries supplemented that with donations.)The African Union, which ordered 220 million doses, has fared better. It has been receiving doses on or ahead of schedule, with the bulk of the order due in the next eight months.Dr. Seth Berkley, who helps run Covax as the chief executive of Gavi, said the Johnson & Johnson vaccine had been at the center of the program’s strategy for fighting Covid last year. But because of Johnson & Johnson’s delay in delivering doses, Covax has increasingly looked to other vaccine providers.“We really needed their doses in 2021, and we were counting on them,” Dr. Berkley said. “They didn’t deliver. So we had to find other doses to meet the countries’ needs.”An African Union official said the bloc was also concerned by the decision to pause production at the Leiden plant because it had been assured that all of its vaccine would come from that facility. The official said Johnson & Johnson’s move raised doubts about whether the bloc would exercise an option to buy an additional 180 million Johnson & Johnson doses.Johnson & Johnson has already faced criticism for failing to prioritize people in developing countries for its Covid vaccine. Last summer, the head of the World Health Organization rebuked the companyafter The Times reported that millions of doses that had been bottled in South Africa were being exported for distribution in Europe.To make its Covid vaccine, Johnson & Johnson relies on a sprawling international network. In addition to the company-run Leiden facility, factories in India, Baltimore and North Carolina have been hired to make the substance of the vaccine. Others, including a plant in South Africa, handle the so-called fill-finish process of bottling and packaging doses.From the start, Johnson & Johnson executives told U.S. officials that they planned to eventually pull the Leiden facility out of the rotation so it could make other products, according to current and former U.S. officials.Johnson & Johnson's factory in the Netherlands has been a linchpin of the company’s vaccine production network.Credit...Piroschka Van De Wouw/ReutersThat was before Johnson & Johnson’s network was overrun with problems.Johnson & Johnson hired a contractor, Emergent BioSolutions, to produce its vaccine at a Baltimore plant that is big enough to make the equivalent of up to a billion doses a year. Emergent, however, failed to meet federal manufacturing standards, and regulators forced the plant to suspend production last April.The factory restarted in August, but regulators with the Food and Drug Administration have not yet determined that it can consistently operate in compliance with manufacturing standards, officials said.As a result, the F.D.A. has insisted on reviewing individual batches of vaccines before they are shipped to be bottled. Regulators haven’t cleared any batches made since the factory reopened, said Matt Hartwig, a spokesman for Emergent.Plans are underway for two other facilities — one a Merck plant in North Carolina, the other run by Biological E in India — to start contributing batches of the Johnson & Johnson vaccine. But those plants are not yet producing usable vaccine substance and are not expected to do so until late spring.The Merck plant — whose participation in the vaccine production the White House last year hailed as a “historic” breakthrough — was supposed to be producing batches as early as last fall. That timeline has since been pushed back to late spring, federal officials said.The delays at Merck and Emergent increased the importance of the Leiden plant. After a renovation last year, the facility had the capacity to produce the equivalent of well over 50 million Covid vaccine doses a month, said two people familiar with the matter.Unlike companies such as Pfizer and Moderna, which have reaped billions of dollars in profits, Johnson & Johnson did not find the Covid vaccine to be a big moneymaker.Johnson & Johnson vowed to sell its vaccine on a not-for-profit basis. The vaccine generated about $2.4 billion in sales last year, less than 3 percent of the company’s total revenue.The Leiden facility had the capacity to produce the equivalent of well over 50 million Covid vaccine doses per month.Credit...Rob Engelaar/Agence France-Presse, via Getty ImagesSince production of the Covid vaccine was halted late last year, the Netherlands plant has been manufacturing an experimental vaccine against respiratory syncytial virus, or R.S.V., that will be used for a clinical trial in older adults in wealthy countries, a person familiar with the matter said. Even if it proves effective, the vaccine is not expected to become available for several years.Mr. Sargent, the Johnson & Johnson spokesman, said the company’s manufacturing sites “produce multiple products, as we have an obligation to supply life-changing medicines to patients around the world.”Johnson & Johnson is among several companies racing to develop the first vaccine for R.S.V., which kills an estimated 14,000 older adults in the United States annually.As with other medical products, the company that wins the first approval is poised to have an advantage in capturing a big share of a market that some analysts think could be worth $10 billion annually by 2030.The vaccine is likely to be aimed at people in wealthy countries, since adults in the developing world are rarely tested for R.S.V.Even with the Leiden plant no longer making the Covid vaccine, Mr. Sargent said Johnson & Johnson continued to provide batches to all of the sites that were handling bottling.One of those is Aspen Pharmacare in South Africa. Stephen Saad, Aspen’s chief executive, said the Leiden shutdown had not interrupted the supply of vaccine to Aspen’s factory.Johnson & Johnson is preparing to return the Leiden facility to making the Covid vaccine next month.But that won’t translate into an immediate gusher of new doses. The facility’s production will undergo testing and inspections. Doses made from the restarted Leiden production most likely won’t be shipped until May or June.","kind":"news","is_publish_news":true,"is_publish_highlight":true,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"0","news_tag":"","news_rank":0,"symbols":[],"gpt_button":1},"commentList":[{"id":9096242142,"gmtCreate":1644410708984,"gmtModify":1676533922394,"author":{"id":"4092752855658210","authorId":"4092752855658210","name":"benjam","avatar":"https://static.tigerbbs.com/43ef1cd3d0888e7ba96239735fab4b58","vip":1,"crmLevel":2,"crmLevelSwitch":0,"idStr":"4092752855658210","authorIdStr":"4092752855658210"},"htmlText":"One wonders how long the delay will last.&nbsp;","listText":"One wonders how long the delay will last.&nbsp;","text":"One wonders how long the delay will last.","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://ttm.financial/post/9096242142","repostId":1147805649,"repostType":4,"isVote":1,"likeStatus":false,"favoriteStatus":false,"reportStatus":false,"tweetType":1,"langContent":"EN"},{"id":9096616893,"gmtCreate":1644372035720,"gmtModify":1676533918359,"author":{"id":"4087190594214920","authorId":"4087190594214920","name":"PBL77","avatar":"https://static.tigerbbs.com/8ef4f93ba3e261ac276aef28c4467365","vip":1,"crmLevel":5,"crmLevelSwitch":0,"idStr":"4087190594214920","authorIdStr":"4087190594214920"},"htmlText":"[Cool]&nbsp;","listText":"[Cool]&nbsp;","text":"[Cool]","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://ttm.financial/post/9096616893","repostId":1147805649,"repostType":4,"isVote":1,"likeStatus":false,"favoriteStatus":false,"reportStatus":false,"tweetType":1,"langContent":"EN"},{"id":9096613881,"gmtCreate":1644371554733,"gmtModify":1676533918321,"author":{"id":"3566631470841362","authorId":"3566631470841362","name":"AiChee","avatar":"https://static.tigerbbs.com/cf64faf9af854b974789eb0c5f58b7e2","vip":1,"crmLevel":3,"crmLevelSwitch":1,"idStr":"3566631470841362","authorIdStr":"3566631470841362"},"htmlText":"👍","listText":"👍","text":"👍","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":1,"commentSize":0,"repostSize":0,"link":"https://ttm.financial/post/9096613881","repostId":1147805649,"repostType":4,"isVote":1,"likeStatus":false,"favoriteStatus":false,"reportStatus":false,"tweetType":1,"langContent":"EN"},{"id":9096635414,"gmtCreate":1644370919516,"gmtModify":1676533918192,"author":{"id":"3581990957315863","authorId":"3581990957315863","name":"newminted","avatar":"https://static.tigerbbs.com/f7fb0ce2c2c4a88e9708e5c7eaf6cfbf","vip":1,"crmLevel":7,"crmLevelSwitch":0,"idStr":"3581990957315863","authorIdStr":"3581990957315863"},"htmlText":"Ok","listText":"Ok","text":"Ok","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":2,"commentSize":0,"repostSize":0,"link":"https://ttm.financial/post/9096635414","repostId":1147805649,"repostType":4,"isVote":1,"likeStatus":false,"favoriteStatus":false,"reportStatus":false,"tweetType":1,"langContent":"EN"},{"id":9096632942,"gmtCreate":1644370767465,"gmtModify":1676533918162,"author":{"id":"3574715591870441","authorId":"3574715591870441","name":"GeraldLee","avatar":"https://static.tigerbbs.com/7455e2a2eb175ec763af1f094563a53f","vip":1,"crmLevel":2,"crmLevelSwitch":0,"idStr":"3574715591870441","authorIdStr":"3574715591870441"},"htmlText":"세상에! 어떻게??&nbsp;","listText":"세상에! 어떻게??&nbsp;","text":"세상에! 어떻게??","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":1,"commentSize":0,"repostSize":0,"link":"https://ttm.financial/post/9096632942","repostId":1147805649,"repostType":4,"isVote":1,"likeStatus":false,"favoriteStatus":false,"reportStatus":false,"tweetType":1,"langContent":"EN"},{"id":9096630604,"gmtCreate":1644369941109,"gmtModify":1676533918054,"author":{"id":"3581947337293370","authorId":"3581947337293370","name":"Ku9787","avatar":"https://static.tigerbbs.com/673e038dbe2974017866e5beb5d79032","vip":1,"crmLevel":8,"crmLevelSwitch":0,"idStr":"3581947337293370","authorIdStr":"3581947337293370"},"htmlText":"Hmm","listText":"Hmm","text":"Hmm","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":2,"commentSize":0,"repostSize":0,"link":"https://ttm.financial/post/9096630604","repostId":1147805649,"repostType":4,"isVote":1,"likeStatus":false,"favoriteStatus":false,"reportStatus":false,"tweetType":1,"langContent":"EN"},{"id":9096695230,"gmtCreate":1644369639641,"gmtModify":1676533918007,"author":{"id":"3582461179498852","authorId":"3582461179498852","name":"Jloong","avatar":"https://static.tigerbbs.com/c4b2ad914ca2d224c8a40f6783470de6","vip":1,"hat":"https://static.tigerbbs.com/0a8758340a08196056f8bc1e54805193","crmLevel":4,"crmLevelSwitch":1,"idStr":"3582461179498852","authorIdStr":"3582461179498852"},"htmlText":"U","listText":"U","text":"U","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":3,"commentSize":0,"repostSize":0,"link":"https://ttm.financial/post/9096695230","repostId":1147805649,"repostType":4,"isVote":1,"likeStatus":false,"favoriteStatus":false,"reportStatus":false,"tweetType":1,"langContent":"EN"}],"hasMoreComments":true,"newsSizeData":{"likeSize":128,"commentSize":7,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false}}