Palatin Presents PL8177 Data at American College of Gastroenterology Annual Meeting

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Palatin Presents PL8177 Data at American College of Gastroenterology Annual Meeting

PR Newswire2022-10-25

Preclinical data shows efficacy in animal models of ulcerative colitis Human pharmacokinetic data show oral formulation releases PL8177 in colon CRANBURY, N.J., Oct. 24, 2022 /PRNewswire/ -- Palatin ...

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(NYSE American: PTN), a biopharmaceutical company developing first-in-class medicines based on molecules that modulate the activity of the melanocortin receptor system, today announced that John Dodd, Ph.D. presented the poster \"Efficacy of the Melanocortin Receptor Agonist PL8177 as a Potential Therapy for Gastrointestinal Inflammatory Diseases\" at the American College of Gastroenterology annual meeting in Charlotte, North Carolina.\n\n  \n\nThe data presented demonstrated that in animal models of ulcerative colitis, oral PL8177 was efficacious in reducing colonic damage and inflammation. In addition, in a Phase 0 human pharmacokinetic study, the oral formulation of PL8177 was released in the colon and importantly, did not enter into systemic circulation. The detailed PL8177 preclinical data has been accepted for publication in an upcoming peer reviewed scientific publication.\nThe poster can be found on Palatin's website www.palatin.com.\n\"We are very proud of the quality of our research and clinical development work and for the opportunity to present at such an important meeting,\" stated Carl Spana, Ph.D., President and CEO of Palatin. \"The presentation summarizes the data that supports the potential of PL8177 as a treatment option for ulcerative colitis patients as an alternative therapy to immunosuppressive treatments, which have significant safety and tolerability concerns.\"\nAn oral formulation of the melanocortin-1 receptor agonist (MC1r) PL8177 is being evaluated in the Phase 2 clinical study PL8177-205 in patients with ulcerative colitis. An interim assessment is currently expected to occur in the first quarter of calendar year 2023, with final topline data anticipated in the third quarter of calendar year 2023. Additional trial information, including inclusion and exclusion criteria, can be found at https://clinicaltrials.gov/ via the identifier NCT05466890.\n\nAbout PL8177\n\nPL8177 is a synthetic cyclic heptapeptide with demonstrated efficacy in multiple animal inflammatory bowel disease models. PL8177 is a potent, selective agonist at the human melanocortin receptor-1 (MC1r), with sub-nanomolar affinity binding and EC50 functional values. Palatin data demonstrates that the oral formulation of PL8177 was protected from degradation in the stomach and small intestine and delivered to the large intestine and colon over an extended period. In addition, orally administered PL8177 had a significant effect on resolving inflammation in a rat bowel inflammation model.\nPL8177 in oral formulations has demonstrated repeated, robust efficacy in ulcerative colitis disease models. MC1r is found on epithelial cells and resident macrophages of the colon which are accessible from the lumen of the colon. Orally administered PL8177 is not systemically absorbed. PL8177 has the potential for excellent efficacy without safety concerns.\n\nAbout Ulcerative Colitis\n\nUlcerative colitis is a chronic disease of the large intestine (colon), with inflammation and ulcerations that can cause significant abdominal pain, persistent diarrhea, loss of appetite and other symptoms. An estimated 1 million individuals in the United States are affected by ulcerative colitis, with over 350,000 diagnosed with moderate-to-severe disease. Existing treatments are not effective in a substantial portion of patients with moderate-to-severe ulcerative colitis, with certain severe cases resulting in surgical removal of the colon.\n\nAbout Melanocortin Receptor Agonists and Inflammation\n\nThe melanocortin receptor (\"MCr\") system has effects on inflammation, immune system responses, metabolism, food intake, and sexual function. There are five melanocortin receptors, MC1r through MC5r. Modulation of these receptors, through use of receptor-specific agonists, which activate receptor function, or receptor-specific antagonists, which block receptor function, can have medically significant pharmacological effects. Many tissues and immune cells located throughout the body, including the gut, kidney and eye, express melanocortin receptors, empowering our opportunity to directly activate natural pathways to resolve disease inflammation.\n\nAbout Palatin\n\nPalatin is a biopharmaceutical company developing first-in-class medicines based on molecules that modulate the activity of the melanocortin receptor systems, with targeted, receptor-specific product candidates for the treatment of diseases with significant unmet medical need and commercial potential. Palatin's strategy is to develop products and then form marketing collaborations with industry leaders to maximize their commercial potential. For additional information regarding Palatin, please visit Palatin's website at www.Palatin.com and follow Palatin on Twitter at @PalatinTech.\n\nForward-looking Statements\n\nStatements in this press release that are not historical facts, including statements about future expectations of Palatin, such as statements about PL8177 clinical trials and results, are \"forward-looking statements\" within the meaning of Section 27A of the Securities Act of 1933, Section 21E of the Securities Exchange Act of 1934 and as that term is defined in the Private Securities Litigation Reform Act of 1995. Palatin intends that such forward-looking statements be subject to the safe harbors created thereby. Such forward-looking statements involve known and unknown risks, uncertainties and other factors that could cause Palatin's actual results to be materially different from its historical results or from any results expressed or implied by such forward-looking statements. Palatin's actual results may differ materially from those discussed in the forward-looking statements for reasons including, but not limited to, results of clinical trials, regulatory actions by the FDA and other regulatory and the need for regulatory approvals, Palatin's ability to fund development of its technology and establish and successfully complete clinical trials, the length of time and cost required to complete clinical trials and submit applications for regulatory approvals, products developed by competing pharmaceutical, biopharmaceutical and biotechnology companies, commercial acceptance of Palatin's products, and other factors discussed in Palatin's periodic filings with the Securities and Exchange Commission. Palatin is not responsible for updating for events that occur after the date of this press release.\n\n\n View original content to download multimedia:https://www.prnewswire.com/news-releases/palatin-presents-pl8177-data-at-american-college-of-gastroenterology-annual-meeting-301657768.html\nSOURCE Palatin Technologies, Inc.","kind":null,"is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"0","news_tag":"","news_rank":0,"symbols":[],"gpt_button":1},"commentList":[{"id":9982142293,"gmtCreate":1667131109013,"gmtModify":1676537865094,"author":{"id":"4098789595583910","authorId":"4098789595583910","name":"Lsiang","avatar":"https://static.tigerbbs.com/62eed67ef2903480b12edb04a756fb53","vip":1,"crmLevel":3,"crmLevelSwitch":0,"idStr":"4098789595583910","authorIdStr":"4098789595583910"},"htmlText":"Okiee","listText":"Okiee","text":"Okiee","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":1,"commentSize":0,"repostSize":0,"link":"https://ttm.financial/post/9982142293","repostId":2278278971,"repostType":2,"repost":{"id":"2278278971","pubTimestamp":1666647120,"share":"https://ttm.financial/m/news/2278278971?lang=&edition=fundamental","pubTime":"2022-10-25 05:32","market":"us","language":"en","title":"Palatin Presents PL8177 Data at American College of Gastroenterology Annual Meeting","url":"https://stock-news.laohu8.com/highlight/detail?id=2278278971","media":"PR Newswire","summary":"Preclinical data shows efficacy in animal models of ulcerative colitis\nHuman pharmacokinetic data sh","content":"<div>\n<p>Preclinical data shows efficacy in animal models of ulcerative colitis\nHuman pharmacokinetic data show oral formulation releases PL8177 in colon\n\nCRANBURY, N.J., Oct. 24, 2022 /PRNewswire/ -- Palatin ...</p>\n\n<a href=\"https://finance.yahoo.com/news/palatin-presents-pl8177-data-american-213200784.html\">Web Link</a>\n\n</div>\n","source":"yahoofinance","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; 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(NYSE American: PTN), a biopharmaceutical company developing first-in-class medicines based on molecules that modulate the activity of the melanocortin receptor system, today announced that John Dodd, Ph.D. presented the poster \"Efficacy of the Melanocortin Receptor Agonist PL8177 as a Potential Therapy for Gastrointestinal Inflammatory Diseases\" at the American College of Gastroenterology annual meeting in Charlotte, North Carolina.\n\n  \n\nThe data presented demonstrated that in animal models of ulcerative colitis, oral PL8177 was efficacious in reducing colonic damage and inflammation. In addition, in a Phase 0 human pharmacokinetic study, the oral formulation of PL8177 was released in the colon and importantly, did not enter into systemic circulation. The detailed PL8177 preclinical data has been accepted for publication in an upcoming peer reviewed scientific publication.\nThe poster can be found on Palatin's website www.palatin.com.\n\"We are very proud of the quality of our research and clinical development work and for the opportunity to present at such an important meeting,\" stated Carl Spana, Ph.D., President and CEO of Palatin. \"The presentation summarizes the data that supports the potential of PL8177 as a treatment option for ulcerative colitis patients as an alternative therapy to immunosuppressive treatments, which have significant safety and tolerability concerns.\"\nAn oral formulation of the melanocortin-1 receptor agonist (MC1r) PL8177 is being evaluated in the Phase 2 clinical study PL8177-205 in patients with ulcerative colitis. An interim assessment is currently expected to occur in the first quarter of calendar year 2023, with final topline data anticipated in the third quarter of calendar year 2023. Additional trial information, including inclusion and exclusion criteria, can be found at https://clinicaltrials.gov/ via the identifier NCT05466890.\n\nAbout PL8177\n\nPL8177 is a synthetic cyclic heptapeptide with demonstrated efficacy in multiple animal inflammatory bowel disease models. PL8177 is a potent, selective agonist at the human melanocortin receptor-1 (MC1r), with sub-nanomolar affinity binding and EC50 functional values. Palatin data demonstrates that the oral formulation of PL8177 was protected from degradation in the stomach and small intestine and delivered to the large intestine and colon over an extended period. In addition, orally administered PL8177 had a significant effect on resolving inflammation in a rat bowel inflammation model.\nPL8177 in oral formulations has demonstrated repeated, robust efficacy in ulcerative colitis disease models. MC1r is found on epithelial cells and resident macrophages of the colon which are accessible from the lumen of the colon. Orally administered PL8177 is not systemically absorbed. PL8177 has the potential for excellent efficacy without safety concerns.\n\nAbout Ulcerative Colitis\n\nUlcerative colitis is a chronic disease of the large intestine (colon), with inflammation and ulcerations that can cause significant abdominal pain, persistent diarrhea, loss of appetite and other symptoms. An estimated 1 million individuals in the United States are affected by ulcerative colitis, with over 350,000 diagnosed with moderate-to-severe disease. Existing treatments are not effective in a substantial portion of patients with moderate-to-severe ulcerative colitis, with certain severe cases resulting in surgical removal of the colon.\n\nAbout Melanocortin Receptor Agonists and Inflammation\n\nThe melanocortin receptor (\"MCr\") system has effects on inflammation, immune system responses, metabolism, food intake, and sexual function. There are five melanocortin receptors, MC1r through MC5r. Modulation of these receptors, through use of receptor-specific agonists, which activate receptor function, or receptor-specific antagonists, which block receptor function, can have medically significant pharmacological effects. Many tissues and immune cells located throughout the body, including the gut, kidney and eye, express melanocortin receptors, empowering our opportunity to directly activate natural pathways to resolve disease inflammation.\n\nAbout Palatin\n\nPalatin is a biopharmaceutical company developing first-in-class medicines based on molecules that modulate the activity of the melanocortin receptor systems, with targeted, receptor-specific product candidates for the treatment of diseases with significant unmet medical need and commercial potential. Palatin's strategy is to develop products and then form marketing collaborations with industry leaders to maximize their commercial potential. For additional information regarding Palatin, please visit Palatin's website at www.Palatin.com and follow Palatin on Twitter at @PalatinTech.\n\nForward-looking Statements\n\nStatements in this press release that are not historical facts, including statements about future expectations of Palatin, such as statements about PL8177 clinical trials and results, are \"forward-looking statements\" within the meaning of Section 27A of the Securities Act of 1933, Section 21E of the Securities Exchange Act of 1934 and as that term is defined in the Private Securities Litigation Reform Act of 1995. Palatin intends that such forward-looking statements be subject to the safe harbors created thereby. Such forward-looking statements involve known and unknown risks, uncertainties and other factors that could cause Palatin's actual results to be materially different from its historical results or from any results expressed or implied by such forward-looking statements. Palatin's actual results may differ materially from those discussed in the forward-looking statements for reasons including, but not limited to, results of clinical trials, regulatory actions by the FDA and other regulatory and the need for regulatory approvals, Palatin's ability to fund development of its technology and establish and successfully complete clinical trials, the length of time and cost required to complete clinical trials and submit applications for regulatory approvals, products developed by competing pharmaceutical, biopharmaceutical and biotechnology companies, commercial acceptance of Palatin's products, and other factors discussed in Palatin's periodic filings with the Securities and Exchange Commission. Palatin is not responsible for updating for events that occur after the date of this press release.\n\n\n View original content to download multimedia:https://www.prnewswire.com/news-releases/palatin-presents-pl8177-data-at-american-college-of-gastroenterology-annual-meeting-301657768.html\nSOURCE Palatin Technologies, Inc.","news_type":1},"isVote":1,"likeStatus":false,"favoriteStatus":false,"reportStatus":false,"tweetType":1,"langContent":"EN"}],"hasMoreComments":true,"newsSizeData":{"likeSize":1,"commentSize":1,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false}}